Surgery – Diagnostic testing – Respiratory
Patent
1997-04-09
2000-01-04
Weiss, John G.
Surgery
Diagnostic testing
Respiratory
600529, 12820026, A61B 508
Patent
active
060104597
ABSTRACT:
Methods and related equipment for measuring components of exhaled breath of a subject are provided which involve causing the subject to exhale into an appropriate apparatus for receiving exhaled breath; increasing the pressure in the mouth of the subject to a level sufficient to close the vellum and isolate the nasopharynx during exhalation; a means of monitoring nasal CO.sub.2 to conrirm vellum closure; and measuring the level of one or more components of the collected exhaled breath. Endogenous nitric oxide is a preferred component of exhaled breath for monitoring and analysis.
REFERENCES:
patent: 3726270 (1973-04-01), Griffis et al.
patent: 3785370 (1974-01-01), Richards et al.
patent: 3951607 (1976-04-01), Fraser
patent: 4083367 (1978-04-01), Portner et al.
patent: 4090078 (1978-05-01), Heim
patent: 4090518 (1978-05-01), Elam
patent: 4202352 (1980-05-01), Osborn
patent: 4688568 (1987-08-01), Frass et al.
patent: 4735777 (1988-04-01), Mitsui et al.
patent: 4772559 (1988-09-01), Preti et al.
patent: 4796639 (1989-01-01), Snow et al.
patent: 4872483 (1989-10-01), Shah
patent: 5042501 (1991-08-01), Kenney et al.
patent: 5081871 (1992-01-01), Glaser
patent: 5443063 (1995-08-01), Greenberg
patent: 5447165 (1995-09-01), Gustafsson
patent: 5474060 (1995-12-01), Evans
patent: 5531218 (1996-07-01), Krebs
patent: 5651358 (1997-07-01), Briend et al.
patent: 5653229 (1997-08-01), Greenberg
patent: 5795787 (1998-08-01), Silkoff et al.
Brooks, Lee J. et al., "Reproducibility and accuracy of airway area by acoustic reflection;" J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 57(3): 777-787, 1984.
Fredberg, Jeffrey et al. "Acoustic Determinants of Respiratory System Properties" A special issue of Annals of Biomedical Engineering, Pergamon Press, New York (Gerald M. Saidel et al., eds) 9: 463-473 (1981).
Fredberg, Jeffrey J. et al., "Airway area by acoustic reflections measured at the mouth;" J. Appl. Physiol.: Respirat. Environ. Exercise Physiol. 48(5):749-758, 1980.
Kimberly, Brent et al. "Nasal Contribution to Exhaled Nitric Oxide at Rest and during Breathholding in Humans" The American Journal of Respiratory and Critical Care Medi 153:829-836, 1996.
Massaro, AF et al. "Expired nitric oxide levels during treatment of acute asthma" Am. J. Respi., Critical Care Med. vol. 152, No. 2, Aug. 1995, 800-803.
Paredi, P. et al., "Factors Influencing Exhaled Nitric Oxide Levels During Reservoir Collection for Subsequent or Delayed Analysis", American Journal of Respiratory and Critical Care Medicine vol. 157:A614, Mar. 1998.
Robbins, RA et al. "Measurement of exhaled nitric oxide by three different techniques", Am. J. Respir. Crit. Care Med., vol. 153, No. 5, May 1996, 1631-1635.
Rubinstein, I. et al., "Effect of mouthpiece, noseclips, and head position on airway area measured by acoustic reflections;" J. Appl. Physiol. 63(4): 1469-1474, 1987.
Sidell, R. et al., Noninvasive Inference of Airway Network Geometry From Broadband Lung Reflection Data; Journal of Biomechanical Engineering, vol. 100, pp. 131-138, 1978.
Silkoff, P. et al., "A technique to minimise the contribution of nasal nitric oxide to that measured at the mouth in humans;" The American Journal of Respiratory and Critical Care Medi 151(4):239, 1995.
Anggard, E.; "Nitric Oxide: mediator, murderer, and medicine; review article"; The Lancet; May 1994; vol. 343; No. 8907, p. 1199.
Borland, CDR., et al.,; "A simultaneous single breath measurement of pulmonary diffusing capacity with nitric oxide and carbon monoxide"; Eur Respir J; 1989, 2, pp. 56-63.
Brett, S.J. et al.; "Endogenous Nitric Oxide in Exhaled Human Breath"; Chest;110,4,Oct. 1996, p.873.
Fallat, R. et al.; "Distribution of Ventillation"; in Wilson, A.F., Editor, "Pulmonary Function Testing Indications and Interpretations"; Pulmonary Function Testing Indications and Interpretations; Grune & Stratton, Inc. (1985).
Guenard, H. et al.; "Determination of lung capilary blood volume and membrane diffusing capacity in man. . . "; Respiration Physiology (1987) 70, pp. 113-120.
Gustafsson, L.E.; Endogenous Nitric Oxide is Present in the Exhaled Air of Rabbits, Guinea Pigs and Humans; Biochem. and Biophys. Res. Com. vol. 181, No. 2, Dec. 16, 1991; pp. 852-857.
Hills, E.A. et al.; "Membrane diffusing capacity and pulmonary capillary volume in rheumatoid disease"; Thorax 1980 Nov.; 35 (11); pp. 851-855.
Husain, Mansoor et al.; Exhaled Nitric Oxide as a Marker for Organic Nitrate Tolerance; Circulation, vol. 89, No. 6, Jun. 1994, #2498 on p. A19.
Kharitonov, S.A. et al.; "Increased nitric oxide in exhaled air of asthmatic patients"; The Lancet; vol. 343 (Jan. 15, 1994), pp. 133-135.
Kilbourn, R.G., et al.; "Endothelial Cell Production of Nitrogen Oxides in Response to Interferon. . . "; HHS; NCI, J Natl Cancer Inst., May 2, 1990; pp. 32-38.
Leone, A.M. et al.; "Nitric Oxide is Present in Exhaled Breath in Humans. . . "; Biochemical and Biophysical Research Communications; vol. 201, No. 2, 1994, pp. 883-887.
Lundberg, Jon, "Airborne Nitric Oxide: Inflammatory Marker. . . "; Acta Physiologica Scandinavica Supplementum 633; Stockholm 1996; pp. 1-27.
Manicatide M.A. et al.; "Breathlessness and transfer factor for the lung. . . "; Rev. Roum Med Intern 1975; 13(1); pp. 53-57 (Abstract Only).
Meyer, M.et al.; "Nitric oxide (NO), a new test gas. . . "; Eur Respir J., 1989, vol. 2, pp. 494-496.
Moinard, J.et al.; "Determination of lung capillary blood volume and membrane diffusing capacity. . . "; Eur Respir J; 1990, 3, pp. 318-322.
Moncada, S.; "Nitric Oxide"; Journal of Hypertension; 1994, 12 (Suppl. 10); pp. S35-S39.
Morrison, D.et al.; "Reduced Exercise Capacity of Chronic Obstructive Pulmonary. . . "; The American Journal of Cardiology; vol. 64; Nov. 15, 1989, pp. 1180-1184.
Nathan, Carl F., et al.; "Does Endothelium-Derived Nitric Oxide Have a Role in Cytokine-Induced Hypotension?"; Journal of National Cancer Institute; May 2, 1990, 82: pp. 726-728.
Persson; Magnus G. et al.; "Single-breath nitric oxide measurements in asthmatic patients and smokers"; The Lancet; vol. 343 (Jan. 15, 1994).
Persson; M.G. et al.; "Endogenous nitric oxide as a probable modulator. . . "; Acta Physiol Scand 1990, 140; pp. 449-457.
Scheideler, L., et al.; "Detection of Nonvolatile Macromolecules. . . "; Am Rev Respir Dis., vol. 148; 1993; pp. 778-784.
Sherman, M.P. et al.; "Cytokine- and Pneumocystic carinii-induced L-arginine oxidation. . . " J Protozool 1991 Nov.-Dec.; 38 (6); pp. 234S-236S (Abstract Only).
Silkoff, P.E. et al., "Marked Flow-dependence of Exhaled Nitric Oxide. . . ", American Journal of Respiratory and Critical Care Medicine; vol. 155; 1997, pp. 260-267.
Swenson, E. et al.; "Conducting airway gas exchange: diffusion-related differences in inert gas elimination"; Airway Gas Exchange; 1992; pp. 1581-1588.
Vane, John R. et al.; "Mechanisms of Disease, Regulatory Functions. . . "; New England Journal of Medicine; Jul. 5, 1990; 323: pp. 27-36.
Yoshida, K. et al.; "Biotransformation of Nitric Oxide, Nitrite and Nitrate"; Int. Arch Occup Environ Health (1983) 52:103-115.
Yoshida, K. et al.; "Biotransformation of Nitric Oxide"; Environmental Health Perspectives; vol. 73, pp. 201-206 (1987).
McClean Patricia A.
Silkoff Philip E.
Weiss John G.
Weiss, Jr. Joseph F.
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