Chemistry: analytical and immunological testing – Nitrogen containing – Oxides of nitrogen
Patent
1994-03-08
1995-07-18
Redding, David A.
Chemistry: analytical and immunological testing
Nitrogen containing
Oxides of nitrogen
436136, 436172, 422 8206, 422 8208, 356 731, G01N 2131, G01N 2164, G01N 3352
Patent
active
054340853
ABSTRACT:
A method for assaying superoxide (O.sub.2.sup.-) or nitric oxide (NO) in an aqueous sample includes an initial step of trapping O.sub.2.sup.- or NO in an emulsion or micellar suspension of a trapping solvent, then reacting the trapped analyte with an appropriate analytical reagent. A flow apparatus for carrying out the method is disclosed. Specific reaction conditions for using chemiluminescence to measure the analytes are also disclosed.
REFERENCES:
patent: 3659100 (1972-04-01), Anderson et al.
patent: 5238610 (1993-08-01), Thompson
patent: 5252494 (1993-10-01), Walt
patent: 5322799 (1994-06-01), Miller et al.
Greenlee, L. et al. (1962), "Chemiluminescence Induced by Operation of Iron-Flavoproteins," Biochemistry 1:779-783.
Huu, T. P. et al. (1984), "Luminol Assay for Microdetermination of Superoxide Dismutase Activity: Its Application to Human Fetal Blood," Anal. Biochem. 142:467-472.
Corbisier, P. et al. (1987), "A New Technique for Highly Sensitive Detection of Superoxide Dismutase Activity by Chemiluminescence," Anal. Biochem. 164:240-247.
Pascual, C. et al. (1992), "A New Luminol Sensitized Chemiluminescence Method for Determination of Superoxide Dismutase," Anal. Lett. 25:837-849.
Peters, T. R. et al. (1990), "Lucigenin Chemiluminescence as a Probe for Mesuring Reactive Oxygen Species Production in Escherichia coli," Anal. Biochem. 186:316-319.
Archer et al. (1989), "Simultaneous Measurement of O.sub.2 Radicals and Pulmonary Vascular Reactivity in Rat Lung," J. Appl. Physiol. 67:1903-1911.
Archer et al. (1989), "Detection of Activated O.sub.2 Species In Vitro and in Rat Lungs by Chemiluminescence," J. Appl. Physiol. and 1912-1921.
Henry et al. (1990), "Enhanced Chemiluminescence as a Measure of Oxygen-Derived Free Radical Generation During Ischemia and Reperfusion," Circulation Res. 67:1453-1461.
Gyllenhammar (1987), "Lucigenin Chemiluminescence in the Assessment of Neutrophil Superoxide Production," J. Immunol. Meth. 97:209-213.
Zafiriou, O. P. et al. (1980), "Determination of Trace Levels of Nitric Oxide in Aqueous Solution," Anal. Chem. 52:1662-1667.
Kikuchi, K. et al. (1993), "Detection of Nitric Oxide Production from a Perfused Organ by a Luminol--H.sub.2 O.sub.2 System," Anal. Chem. 65:1794-1799.
Radi, R. et al. (1993), "Peroxynitrite-induced Luminol Chemiluminescence," Biochem. J. 290:51-57.
Saran and Bors (1991), "Direct and Indirect Measurements of Oxygen Radicals," Klin. Wochenschrift 69:957-964.
Capomacchia Tony
Do Ngoc H.
Redding David A.
University of Georgia Research Foundation Inc.
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