Method and apparatus for stirring particles in suspension such a

Details Method and apparatus for stirring particles in suspension such a Method and apparatus for stirring particles in suspension such a

1981-06-25

1983-05-10

Jenkins, Robert W.

Agitating

Stirrer within stationary mixing chamber

366242, 366306, 366348, 366349, 422 99, 422228, 435316, B01F 308

Patent

active

043826857

ABSTRACT:
Stirring apparatus for stirring particles in a liquid medium comprising a cylindrical stirring vessel having a stirring rod extending within the vessel to stir its contents. The rod has a bulbous tip which describes an orbital path in the vessel to sweep out an annular trough or channel formed in the bottom of the vessel. The annular trough or channel is contoured in section to follow the flow lines set up in the medium by secondary motion stirring effects. In this way accumulation of particles due to the secondary motion, which would otherwise occur at the corners and center of the bottom of the vessel, is avoided. The apparatus is advantageously useful in cell culture research particularly for stirring microcarriers in a liquid culture medium because it becomes possible to maintain the microcarriers in uniform suspension at lower stirring speeds than heretofore possible thus avoiding damage to the growing cells and improving overall cell yield.

REFERENCES:
patent: 235505 (1880-12-01), Buck
patent: 1308038 (1919-07-01), Burnett
patent: 1898094 (1933-02-01), Nies
patent: 2932493 (1960-04-01), Jacobs
patent: 3245665 (1966-04-01), Steel
patent: 3572651 (1971-03-01), Harker
patent: 3576168 (1971-04-01), Thylstrup
patent: 3854704 (1974-12-01), Balas
patent: 3900186 (1975-08-01), Balas

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