Method and apparatus for specific affinity enhanced transport bi

Details Method and apparatus for specific affinity enhanced transport bi Method and apparatus for specific affinity enhanced transport bi

1989-01-23

1990-09-25

Jones, W. Gary

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210645, 210656, 210688, 2101982, 2105071, 210506, 210912, 5253297, 435182, 435288, 422131, 422239, B01D 1508

Patent

active

049591487

ABSTRACT:
A method and apparatus for removing and/or modifying specific target substances in the blood is disclosed. The invention includes a column or chamber in which selected bioreactant molecules are suitably retained for reaction within a porous hydrogel polymer matrix by reversibly quenching the reactant propensity with a displaceable surrogate and polymerizing an insoluble cross-linked hydrogel in such manner that the hydrogel polymer replicates the shape of the bioreactant molecule. This replicated phantom shape in the polymer then exhibits profound dispersion-force affinity for the bioreactant. The invention provides for retention of a wide variety of therapeutic reactants and reaction products while confining the reaction within the column.

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Albert, Adrien, Selective Toxicity, Methven & Co., 1968, pp. 320-321.
Peppas, Nikolaos A. (Ed.), Hydrogels in Medicine and Pharmacy, vol. 1, CRC Press, 1986, pp. 102-103.
Andrade, Joseph D., (Ed.), Hydrogels for Medical and Related Applications, American Chemical Soc., 1976, p. 25.
Chibata, Ichiro (Ed.), Immobilized Enzymes, Halsted Press, 1978, pp.68-70.

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