Optics: measuring and testing – With plural diverse test or art
Reexamination Certificate
2011-08-23
2011-08-23
Evans, F. L. (Department: 2877)
Optics: measuring and testing
With plural diverse test or art
C356S318000, C356S339000, C356S342000, C356S419000, C422S082080, C435S288700, C436S172000, C250S461200
Reexamination Certificate
active
08004661
ABSTRACT:
A method, apparatus, and system for a sorting flow cytometer include an objective lens having an optical axis coaxially aligned with the flow path at the focal point. A controllable energy source selectively alters an analyte according to a determination of whether the analyte is in a desired sub-population. In various embodiments, one or both of the emission from the controllable energy source and/or the emission from an illumination energy source passes through the objective lens. In some embodiments in which the emission from the controllable energy source passes through the objective lens, the objective lens may focus the emission from the controllable energy source at a different point than the focal point of a signal detected from the analyte and, in particular, at a point closer to the objective lens.
REFERENCES:
patent: 2656508 (1953-10-01), Coulter
patent: 3380584 (1968-04-01), Fulwyler
patent: 3497690 (1970-02-01), Wheeless, Jr. et al.
patent: 3657537 (1972-04-01), Wheeless, Jr. et al.
patent: 3710933 (1973-01-01), Fulwyler et al.
patent: 4188542 (1980-02-01), Hogg et al.
patent: 4395397 (1983-07-01), Shapiro
patent: 4629687 (1986-12-01), Schindler et al.
patent: 5135759 (1992-08-01), Johnson
patent: 5406421 (1995-04-01), Kashima et al.
patent: 5658892 (1997-08-01), Flotte et al.
patent: 5739902 (1998-04-01), Gjelsnes et al.
patent: 6010647 (2000-01-01), Nomura et al.
patent: 6143535 (2000-11-01), Palsson
patent: 6534308 (2003-03-01), Palsson et al.
patent: 6594009 (2003-07-01), Saccomanno
patent: 7106528 (2006-09-01), Ohmori et al.
patent: 7118676 (2006-10-01), Mueth et al.
patent: 7193775 (2007-03-01), Olszak et al.
patent: 7355696 (2008-04-01), Mueth et al.
patent: 7586604 (2009-09-01), Sharpe et al.
patent: 2005/0112541 (2005-05-01), Durack et al.
patent: 2005/0194546 (2005-09-01), Saccomanno
patent: 2006/0263829 (2006-11-01), Evans et al.
patent: 2007/0117086 (2007-05-01), Evans et al.
patent: 2008/0144037 (2008-06-01), Mueth et al.
patent: 1815352 (1971-01-01), None
patent: WO-94/22001 (1994-09-01), None
patent: WO-98/34094 (1998-08-01), None
patent: WO-99/05504 (1999-02-01), None
patent: WO-2004/01704 (2004-02-01), None
patent: WO-2004/088283 (2004-10-01), None
patent: WO-2004/104178 (2004-12-01), None
patent: WO-2005/075629 (2005-08-01), None
patent: WO-2008/128630 (2008-10-01), None
patent: WO-2009/014643 (2009-01-01), None
patent: WO-2009/151624 (2009-12-01), None
Garner et al.,Quantification of the X- and Y-Chromosome-Bearing Spermatozoa of Domestic Animals by Flow Cytometry, Biology of Reproduction, vol. 28, No. 2, Mar. 1, 1983, pp. 312-321.
International Search Report and Written Opinion for Application No. PCT/IB2009/006480, dated Feb. 16, 2010.
Takahahi, et al., “Further advancement of wide-angle EUSO telescope with holographic and Fresnel lenses,” 29th International Cosmic Ray Conference Pune 8, pp. 355-358 (2005).
Garner, et al., “Quantification of the X- and Y-Chromosome-Bearing Spermatozoa of Domestic Animals by Flow Cytometry,” Biology of Reproduction 28, pp. 312-321 (1983).
Kawano, et al., “Ultrafast dynamics in a live cell irradiated by femtosecond laser pulses,” Biophotonics 2007: Optics in Life Science, edited by Jurgen Popp, Gert von Bally, Proc. of SPIE-OSA Biomedical Optics, SPIE vol. 6633, pp. 66330J-1-66330J-9(2007).
Pitsillides, et al., “Selective Cell Targeting with Light-Absorbing Microparticles and Nanoparticles,” Biophysical Journal, vol. 84, pp. 4023-4032 (2003).
Hung, et al., “Fluorinated Plastics, Amorphous,” Concise Polymer Materials Encyclopedia, pp. 499-501 (1998).
Herweijer, et al., “High-Speed Photodamage Cell Selection Using Bromodeoxyuridine/Hoechst 33342 Photosensitized Cell Killing,” Cytometry vol. 9, pp. 143-149 (1988).
Pinkel, et al., “High Resolution DNA Content Measurements of Mammalian Sperm,” Cytometry vol. 3, No. 1, pp. 1-9 (1982).
Kerker, et al., “An Optical Model for Fluorescence of Mammalian Sperm in Flow Cytometry,” Cytometry vol. 1, No. 2, pp. 161-167 (1980).
Martin, et al., “Photodamage, a Basis for Super High Speed Cell Selection,” Cytometry vol. 2, p. 2 (Abstract) (1981).
Severin, et al., “A New Flow Chamber and Processing Electronics for Combined Laser and Mercury Arc Illumination in an Impulscytophotometer Flow Cytometer,” Cytometry, vol. 3, No. 4, pp. 308-310 (1983).
Bakker Schut, et al., “A New Principle of Cell Sorting by Using Selective Electroporation in a Modified Flow Cytometer,” Cytometry, vol. 11, pp. 659-666 (1990).
Keij, et al., “Coincidence in High-Speed Flow Cytometry: Models and Measurements,” Cytometry, vol. 12, pp. 398-404 (1991).
Keij, et al., “High-Speed Photodamage Cell Selection Using a Frequency-Doubled Argon Ion Laser,” Cytometry, vol. 19, pp. 209-216 (1995).
Evenson, et al., “Comparative Sperm Chromatin Structure Assay Measurements on Epiillumination and Orthogonal Axes Flow Cytometers,” Cytometry, vol. 19, pp. 295-303 (1995).
Sharpe, et al., “Radially Symmetric Excitation and Collection Optics for Flow Cytometric Sorting of Aspherical Cells,” Cytometry, vol. 29, pp. 363-370 (1997).
Koller, et al., “High-Throughput Laser-Mediated in Situ Cell Purification with High Purity and Yield,” Cytometry Part A, vol. 61A, pp. 153-161 (2004).
Cytop®, “Amorphous Fluorocarbon Polymer,” (undated) Available at http://www.belexinternational.com/Cytopflyer.pdf.
Gledhill, “Cytometry of Mammalian Sperm,” Gamete Research, vol. 12, pp. 423-438 (1985).
Egner, et al., “Aberrations in Confocal and Multi-Photon Fluorescence Microscopy Induced by Refractive Index Mismatch,” Handbook of Biological Confocal Microscopy, third edition, (2006).
Van Dilla, et al., “Measurement of Mammalian Sperm Deoxyribonucleic Acid by Flow Cytometry,” The Journal of Histochemistry and Cytochemistry, vol. 25, No. 7, pp. 763-773 (1977).
Otto, et al., “Flow Cytometry of Human Spermatozoa,” Histochemistry 62, pp. 249-254 (1979).
König, et al., “Effects of ultraviolet exposure and near infrared laser tweezers on human spermatozoa,” Human Reproduction vol. 11 No. 10, pp. 2162-2164 (1996).
Phywe, Impulscytophotometrie ICP11 Book, pp. 1-24 (1973).
Phywe, Impulscytophotometrie ICP 22 Datasheet (1976).
Takizawa, et al., “Advancement of the wide-angle JEM-EUSO optical system with holographic and Fresnel lenses,” 30th International Cosmic Ray Conference ICRC 2007 Proceedings—Pre-Conference Edition (2007).
Zohdy, et al., “Acoustic Estimation of Thermal Distribution in the Vicinity of Femtosecond Laser-Induced Optical Breakdown,” IEEE Transactions on Biomedical Engineering, vol. 53, No. 11, pp. 2347-2355 (2006).
Zohdy, et al., “Optical and Acoustic Detection of Laser-Generated Microbubbles in Single Cells,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 52, No. 1, pp. 117-125 (2006).
Thøgersen, et al., “Reproductive death of cancer cells induced by femtosecond laser pulses,” Int. J. Radiat. Biol., vol. 83, No. 5, pp. 289-299 (2007).
Pinkel, et al., “Flow Cytometric Determination of the Proportions of X-andY-Chromosome-Bearing Sperm in Samples of Purportedly Separated Bull Sperm,” Journal of Animal Science 60:1303-1307, (1985).
Roegener, et al., “Pump-probe detection of laser-induced microbubble formation in retinal pigment epithelium cells,” Journal of Biomedical Optics, vol. 9, No. 2, pp. 367-371 (2004).
Lee, et al., “Optical detection of intracellular cavitation during selective laser targeting of the retinal pigment epithelium: dependence of cell death mechanism on pulse duration,” Journal of Biomedical Optics, vol. 12, No. 6, pp. 064034-1-064034-14 (2007).
Fulwyler, “Hydrodynamic Orientation of Cells,” The Journal of Histochemistry and Cytochemistry, vol. 25, No. 7, pp. 781-
Evans F. L.
Marshall & Gerstein & Borun LLP
Microbix Biosystems Inc.
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