Method and apparatus for sorting biological cells with a...

Details Method and apparatus for sorting biological cells with a... Method and apparatus for sorting biological cells with a...

2007-09-04

2007-09-04

Wallenhorst, Maureen M. (Department: 1743)

Chemistry: analytical and immunological testing

Including sample preparation

Volumetric liquid transfer

C436S043000, C436S046000, C436S063000, C436S149000, C436S164000, C436S165000, C436S172000, C422S082010, C422S082050, C422S082080, C422S105000, C435S029000, C435S030000, C435S287100, C435S288300, C435S288400, C435S288500, C435S288700, C209S003100, C209S552000, C209S576000

Reexamination Certificate

active

10978947

ABSTRACT:
A micromechanical actuator for sorting hematopoietic stem cells for use in cancer therapies. The actuator operates by diverting cells into one of a number of possible pathways fabricated in the fabrication substrate of the micromechanical actuator, when fluorescence is detected emanating from the cells. The fluorescence results from irradiating the cells with laser light, which excites a fluorescent tag attached to the cell. The micromechanical actuator thereby sorts the cells individually, with an operation rate of 3.3 kHz, however with the massively parallel 1024-fold device described herein, a throughput of 3.3 million events/second is achievable.

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