Chemistry: analytical and immunological testing – Including sample preparation – Volumetric liquid transfer
Patent
1986-10-31
1987-09-15
Richman, Barry S.
Chemistry: analytical and immunological testing
Including sample preparation
Volumetric liquid transfer
7386321, 222319, 222386, 422100, G01N 118
Patent
active
046939849
ABSTRACT:
An apparatus for sequentially fractionating a centrifuge tube includes a capillary tube and a means for applying positive pressure. The capillary tube has an O-ring at the lower end thereof. As the capillary tube is placed within the centrifuge tube, the O-ring forms a seal within the tube. Movement of the capillary tube within the centrifuge tube places the liquid in the centrifuge tube under pressure, thus forcing the liquid to flow up through the capillary tube and into a chamber. A chase fluid is then pumped horizontally through the chamber to force the liquid therein through an exit port and into a fraction collector. The apparatus and method of the present invention may be entirely automated and controlled by a single microprocessor.
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Attri et al; Technique and Apparatus for Automated Fractionation of the Contents of Small Centrifuge Tubes Anal. Biochem. 152, 319-328 1986.
Coombs; Density Gradient Fractionation by Piston Displacement; Anal. Biochem. vol. 68, pp. 95-101 (1975).
Attri Arun K.
Minton Allen P.
Sullivan James V.
Gzybowski Michael S.
Richman Barry S.
The United States of America as represented by the Secretary of
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