Chemistry: electrical and wave energy – Processes and products – Electrophoresis or electro-osmosis processes and electrolyte...
Reexamination Certificate
2005-12-27
2005-12-27
Noguerola, Alex (Department: 1753)
Chemistry: electrical and wave energy
Processes and products
Electrophoresis or electro-osmosis processes and electrolyte...
C204S610000, C204S601000, C204S451000
Reexamination Certificate
active
06979390
ABSTRACT:
A system for separating biological molecules includes a chip (10) on which there is an electrophoresis separation microchannel (16). At the start of the channel there is an isoelectric focusing section (14) containing a gel having a pH gradient. Molecules to be separated are placed in the focusing section (14) and move to an equilibrium position under the influence of an electric field. The electrophoretic state of the molecules is then changed, and a high voltage potential applied across the entire length of the focusing and separation sections. The molecules migrate under the influence of the electric field from the focusing section into the separation section where their position and velocity are tracked. From a knowledge of position and velocity, a user can determine both charge/mass ratio and isoelectric equilibrium point for each molecule. The gels can be replicated in the chip to allow parallel analysis, and hence comparisons, to take place.
REFERENCES:
patent: 6676819 (2004-01-01), Liu et al.
patent: 6764817 (2004-07-01), Schneider
patent: WO 96/35946 (1996-11-01), None
patent: WO 00/17631 (2000-03-01), None
patent: WO 02/12876 (2002-02-01), None
patent: WO 02/12877 (2002-02-01), None
patent: WO 02/13122 (2002-02-01), None
International Search Report for International Application No. PCT/GB01/04696 filed Oct. 23, 2001, mailed Feb. 13, 2002.
Hassard John
Hassard Stuart
Sanders Giles Hugo William
Sideris Dimitrios
Deltadot Limited
Noguerola Alex
Wallenstein Wagner & Rockey Ltd.
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