Radiant energy – Ionic separation or analysis – Cyclically varying ion selecting field means
Patent
1995-05-25
1996-11-05
Anderson, Bruce C.
Radiant energy
Ionic separation or analysis
Cyclically varying ion selecting field means
250282, B01D 5944, H01J 4900
Patent
active
055720250
ABSTRACT:
A method of operation of an ion trap mass spectrometer having a ring electrode and pair of end-cap electrodes in a resonance ejection mode is disclosed. The method includes producing ions from a plurality of biomolecules, applying a trapping RF voltage to the ring electrode, applying an excitation voltage to the end-cap electrodes, scanning the trapping RF voltage in order to sequentially eject the ions, controlling a ration of the amplitude of the trapping RF voltage to the amplitude of the excitation voltage in order that the ratio is generally constant, and determining a ratio of mass to charge of the ejected ions. In one embodiment, a feedback voltage which is proportional to the trapping RF voltage is sensed, and the amplitude of the excitation voltage is controlled as a function of the amplitude of the feedback voltage. In another embodiment, a first value related to the amplitude of the trapping RF voltage and a second value, which is proportional to the first value and related to the amplitude of the excitation voltage, are determined. The amplitude of the trapping RF voltage is modulated employing the first value and the amplitude of the excitation voltage is modulated employing the second value. Preferably, the determined mass-to-charge ratio (m/z) of the ejected ions is equal to a constant (.alpha.) times the trapping RF voltage (V). Associated apparatus and method of calibration are also disclosed.
REFERENCES:
patent: Re34000 (1992-07-01), Syka et al.
patent: 2882410 (1959-04-01), Brobeck
patent: 2939952 (1960-06-01), Paul et al.
patent: 3073951 (1963-01-01), Burdg
patent: 3590243 (1971-06-01), Perrin et al.
patent: 3617736 (1971-11-01), Barnett et al.
patent: 3955084 (1976-05-01), Giffin
patent: 4175234 (1979-11-01), Hunt et al.
patent: 4298795 (1981-11-01), Takeuchi et al.
patent: 4473748 (1984-09-01), Konagai et al.
patent: 4500782 (1985-02-01), Allemann et al.
patent: 4540884 (1985-09-01), Stafford et al.
patent: 4736101 (1988-04-01), Syka et al.
patent: 4818864 (1989-04-01), Allemann
patent: 4882485 (1989-11-01), Duryea
patent: 4952802 (1990-08-01), Duryea
patent: 5028777 (1991-07-01), Frazen et al.
patent: 5120957 (1992-06-01), Griffiths
patent: 5155357 (1992-10-01), Hemond
patent: 5291017 (1994-03-01), Wang et al.
patent: 5298746 (1994-03-01), Franzen et al.
patent: 5304799 (1994-04-01), Kurzweg
patent: 5354988 (1994-10-01), Jullien
patent: 5399857 (1995-03-01), Doroshenko et al.
Raymond E. Kaiser,Jr. et al., Operation of a Quadrupole Ion Trap Mass Spectrometer to Achieve High Mass/Charge Ratios, pp. 79-115, 1991, International Journal of Mass Spectrometry and Ion Processes, vol. 106.
Frank A. Londry et al., Enhanced Resolution in a Quadrupole Ion Trap, pp. 43-45, 1993, Rapid Communications In Mass Spectrometry, vol. 7.
Raymond E. March, Ion Trap Mass Spectrometry, pp. 71-135, 1992, International Journal of Mass Spectrometry and Ion Processes, vol. 118-19.
Gary J. Van Berkel et al., Electrospray Ionization Combined with Ion Trap Mass Spectrometry, pp. 1284-1295, Jul. 1990, Analytical Chemistry, vol. 62, No. 13.
Vladimir M. Doroshenko et al., Matrix-assisted Laser Desorption/Ionization Inside a Quadrupole Ion-trap Detector Cell, pp. 753-757, 1992, Rapid Communications in Mass Spectrometry, vol. 6.
K. A. Cox et al., Quadrupole Ion Trap Mass Spectrometry: Current Applications and Future Direction for Peptide Analysis, pp. 226-241, 1992, Biological Mass Spectrometry, vol. 21.
David M. Chambers et al., Matrix-Assisted Laser Desorption of Biological Molecules in the Quadrupole Ion Trap Mass Spectrometer, pp. 14-20, Jan. 1993, Analytical Chemistry, vol. 65, No. 1.
Karen Jonscher et al., Matrix-assisted Laser Desorption of Peptides and Proteins on a Quadrupole Ion Trap Mass Spectrometer, pp. 20-26, 1993, Rapid Communications in Mass Spectrometry, vol. 7.
Jae C. Schwartz et al., Matrix-assisted Laser Desorption of Peptides and Proteins Using a Quadrupole Ion Trap Mass Spectrometer, pp. 27-32, 1993, Rapid Communications in Mass Spectrometry, vol. 7.
Vladimir M. Doroshenko et al., A New Method of Trapping Ions Produced by Matrix-assisted Laser Desorption Ionization in a Quadrupole Ion Trap, pp. 822-827, 1993, Rapid Communications in Mass Spectrometry, vol. 7.
Vladimir M. Doroshenko et al., High-Resolution Matrix-assisted Laser Desorption/Ionization Mass Spectrometry of Biomolecules in a Quadrupole Ion Trap, pp. 513-518, 1994, American Institute of Physics.
Raymond E. Kaiser, Jr. et al., Extending the Mass Range of the Quadrupole Ion Trap Using Axial Modulation, pp. 225-229, 1989, Rapid Communications in Mass Spectrometry, vol. 3.
Douglas E. Goeringer et al., Theory of High-Resolution Mass Spectrometry Achieved via Resonance Ejection in the Quadrupole Ion Trap, pp. 1434-1439, Jul. 1992, Analytical Chemistry, vol. 64, No. 13.
Randall K. Julian, Jr. et al., Large Scale Simulation of Mass Spectra Recorded with a Quadrupole Ion Trap Mass Spectrometer, pp. 85-96, 1993, International Journal of Mass Spectrometry and Ion Processes, vol. 123.
Jon D. Williams et al., Improved Accuracy of Mass Measurement with a Quadrupole Ion-trap Mass Spectrometer, pp. 524-527, 1992, Rapid Communications in Mass Spectrometry, vol. 6.
H. G. Dehmelt, Radiofrequency Spectroscopy of Stored Ions I: Storage: pp. 53-72, 1967, Adv. At. Mol. Phys., vol. 3.
David N. Heller et al., Laser Desorption from a Probe in the Cavity of a Quadrupole Ion Storage Mass Spectrometer, pp. 1083-1086, May 1989, Analytical Chemistry, vol. 61, No. 10.
Ronald C. Beavis et al., Velocity Distributions of Intact High Mass Polypeptide Molecule Ions Produced by Matrix Assisted Laser Desorption, pp. 479-484, Jul. 1991, Chemical Physical Letters, vol. 181, No. 5.
Marc R. Chevrier et al., TOFWARE: A Windows.RTM.-based Data Acquistion System for Time-of-Flight Mass Spectrometry, pp. 1169-1170, 1992, The 40th ASMS Conference on Mass Spectrometry and Allied Topics.
J. P. Carrico, Applications of Inhomogeneous Oscillatory Electric Fields in the Ion Physics, pp. 1-65, 1972, Dyn. Mass Spectrom., vol. 3.
Cotter Robert J.
Doroshenko Vladimir M.
Anderson Bruce C.
Houser Kirk D.
The Johns Hopkins University School of Medicine
LandOfFree
Method and apparatus for scanning an ion trap mass spectrometer does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for scanning an ion trap mass spectrometer , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for scanning an ion trap mass spectrometer will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2016459