Method and apparatus for releasing a controlled amount of aeroso

Surgery – Liquid medicament atomizer or sprayer

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12820023, 12820423, A61M 1100

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active

053927680

ABSTRACT:
A portable, battery powered, hand-held system for releasing a controlled dose of aerosol medication for inhalation by a patient including a durable body and a medication cassette inserted in the durable body. The cassette includes a housing for containing a canister of medication, bears an identification code, and permits the canister to be manually depressed to release a dose, e.g., a metered dose, when out of the durable body. The durable body includes an actuator mechanism for engaging an inserted cassette and its canister, and an actuator release mechanism for controlling the actuator mechanism to depress the canister for a selected period of time to release the desired dose of medication and then the release the canister. The actuator mechanism, includes a compression spring for depressing the canister and a torsion spring for reloading the compression spring. The torsion spring is reloaded by rotating the cassette from an open position for delivering aerosol to a closed position. The actuator release mechanism includes a motor and trigger pin assembly that controls the release of the compression spring and the torsion spring, and, hence, the time that the canister is depressed. The motor operates in response to sensed flow satisfying a selected delivery threshold. The durable body includes a flow sensor having an asymmetrical orifice that is calibrated, independent of the cassette, to convert the sensed pressure due to flow into a flow rate. The orifice is separately calibrated for an inhalation flow rate range and an exhalation flow rate range over a selected number of known flow rates. The sensed pressure value is corrected for transducer offset drift and converted to a flow rate using the calibration data and piecewise linear interpolation.

REFERENCES:
patent: Re29117 (1977-01-01), Sahajian et al.
patent: 3157179 (1964-11-01), Paullus et al.
patent: 3187748 (1965-06-01), Mitchell et al.
patent: 3211346 (1965-10-01), Meshberg
patent: 3356088 (1967-12-01), Nelson
patent: 3394851 (1968-07-01), Gorman
patent: 3456644 (1969-07-01), Thiel
patent: 3456645 (1969-07-01), Brock
patent: 3456646 (1969-07-01), Phillips et al.
patent: 3464596 (1969-09-01), Meshberg
patent: 3565070 (1971-02-01), Hanson et al.
patent: 3636949 (1972-01-01), Kropp
patent: 3658059 (1972-04-01), Steil
patent: 3789843 (1974-02-01), Armstrong et al.
patent: 3814297 (1974-06-01), Warren
patent: 3826413 (1974-07-01), Warren
patent: 3830404 (1974-08-01), Frazer
patent: 3878973 (1975-04-01), Riccio
patent: 3940023 (1976-02-01), Umstead
patent: 3952916 (1976-04-01), Phillips
patent: 3968905 (1976-07-01), Pelton
patent: 3974941 (1976-08-01), Mettler
patent: 3991304 (1976-11-01), Hillsman
patent: 4106503 (1978-08-01), Rosenthal et al.
patent: 4117958 (1978-10-01), Spitzer et al.
patent: 4124149 (1978-11-01), Sptizer et al.
patent: 4256017 (1981-03-01), Eastman
patent: 4291688 (1981-09-01), Kistler
patent: 4361401 (1982-11-01), Smith, Jr. et al.
patent: 4366743 (1983-01-01), Leszczewski
patent: 4386553 (1983-06-01), Thoman et al.
patent: 4413755 (1983-11-01), Brunet
patent: 4427137 (1984-01-01), Dubini
patent: 4446862 (1984-05-01), Baum et al.
patent: 4462398 (1984-07-01), Durkan et al.
patent: 4469255 (1984-09-01), Hill et al.
patent: 4484577 (1984-11-01), Sackner et al.
patent: 4524769 (1985-06-01), Wetterlin
patent: 4534343 (1985-08-01), Nowacki et al.
patent: 4558710 (1985-12-01), Eichler
patent: 4576157 (1986-03-01), Raghuprasad
patent: 4592348 (1986-06-01), Waters, IV et al.
patent: 4624251 (1986-11-01), Miller
patent: 4648393 (1987-03-01), Landis et al.
patent: 4662537 (1987-05-01), Wolf et al.
patent: 4664107 (1987-05-01), Wass
patent: 4677975 (1987-07-01), Edgar et al.
patent: 4679555 (1987-07-01), Sackner
patent: 4682713 (1987-07-01), Clapp
patent: 4702400 (1987-10-01), Corbett
patent: 4745925 (1988-05-01), Dietz
patent: 4790305 (1988-12-01), Zoltan et al.
patent: 4803978 (1989-02-01), Johnson, IV et al.
patent: 4805609 (1989-02-01), Roberts et al.
patent: 4819629 (1989-04-01), Jonson
patent: 4832012 (1989-05-01), Raabe et al.
patent: 4852582 (1989-08-01), Pell
patent: 4860740 (1989-08-01), Kirk et al.
patent: 4896832 (1990-01-01), Howlett
patent: 4922901 (1990-05-01), Brooks et al.
patent: 4926852 (1990-05-01), Zoltan et al.
patent: 4932402 (1990-06-01), Snook et al.
patent: 4933873 (1990-06-01), Kaufman et al.
patent: 4934358 (1990-06-01), Nilsson et al.
patent: 4942544 (1990-07-01), McIntosh et al.
patent: 4984158 (1991-01-01), Hillsman
patent: 5027808 (1991-07-01), Rich et al.
patent: 5069204 (1991-05-01), Smith et al.
patent: 5133343 (1992-07-01), Johnson, IV et al.
"Aerosol Drug Therapy for the Treatment of Obstructive Airway Disease", pp. 3-16, (Schering Laborabories, Kenilworth, N.J.).
Kohler, "Aerosols for Systemic Treatment", Lung, (1990 Suppl:677-684.
3M HealthCare, Product Information, Jul., 1988, "Aerosol Non-sheathed Actuator and Cap".
Newman et al. "Deposition of Pressurized Aerosols in the Human Respiratory Tract" Thorax, 1981 vol. 36, pp. 52-55.
Newman et al. "Deposition of Pressurized Suspension Aerosols Inhaled Through Extension Devices" Am Rev Respir Dis, 1981, vol. 124 pp. 317-320.
Moren "Drug Deposition of pressurized Inhalation Aerosols: II. Influence of Vapour Pressure and Metered Volume", International Journal of Pharmaceuticals, 1 (1978) pp. 213-218.
Newman et al. "How Should a Pressuirized Beta-Adrenergic Bronchodilator be Inhaled?" Eur. J. Respir. Dis., (1981) vol. 62, pp. 3-21.
Sullivan et al., "Pnuemotachographs: Theory and Clinical Application" Respiratory Care, Jul. 1984, vol. 29, No. 7, pp. 736-749.
Bennett, "Targeting Aerosol Delivery in the Lung", Aerosol Age, Nov. 1990, pp. 32-35.
3M HealthCare, Product Information, Jul. 1988, "Aerosol System The Standard of Pharmaceutical Precision".
Byron, (ed)., Respiratory Drug Delivery, CRC Press, Inc. (1990) pp. 173-178.
McIlreath et al, "The Value of an Automatic Inhalation Device for Asthmatic Children", The Journal of Asthma Research, vol. 10, No. 1, Sep. 1972.
Cohen, "`Metered` Aerosols of Bronchodilator Drugs in Clinical Trials", Thorax (1971), vol. 26, pp. 316-318.
Spector et al., "Compliance of Patients with Asthma with an Experimental Aerosolized Medication: Implications for Controlled Clinical Trials" J. Allergy Clin. Immunol. (1986) vol. 77, pp. 65-70.
Gong, Jr. et al., "Metered-dose Inhaler Usage in Subjects with Asthma: Comparison of Nebulizer Chronolog and Daily Diary Recordings" J. Allergy Clin. Immunol. (1988) vol. 82, pp. 5-10.
Cohen, "Color Presentation of Breath Sounds", Respiration, vol. 29, pp. 234-246 (1972).
Heyder "Charting Human Thoracic Airways by Aerosols", Clin. Phys. Physio. Meas., 1983, vol. 4, No. 1, pp. 29-37.
Ryan et al. "Standardization of Inhalation Provocation Tests: Two Techniques of Aerosol Generation and Inhalation Compared" Am. Rev. Respir. Dis., (1981), vol. 123, pp. 195-199.
Chai et al., "Standardization of Bronchial Inhalation Challenge Procedures" J. Allergy Clin. Immunol., vol. 56, No. 4, pp. 323-327 Oct. 1975.
Rosenthal et al. "Role of the Parasympathetic System in Antigen-Induced Bronchospasm" J. Appl. Physiol.: Respirat. Environ. Exercise Phisiol. 42(4) pp. 600-606, 1977.
Nieminen et al., "Aerosol Deposition in Automatic Dosimeter Nebulization" Eur. J. Respir. Dis. (1987) 71, pp. 145-152.
Lee et al. "Aerosol Inhalation Teaching Device" J. Pediatrics, 1987, vol. 110, pp. 249.gtoreq.252.
Newmann, Depostion and Effects of Inhalation Aerosols, 1983 RAHMS; LUND Tryckeri AB.

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