Method and apparatus for primarily ambulatory gastrointestinal r

Details Method and apparatus for primarily ambulatory gastrointestinal r Method and apparatus for primarily ambulatory gastrointestinal r

1996-09-17

1998-10-13

Bahr, Jennifer

Surgery

Diagnostic testing

Measuring or detecting nonradioactive constituent of body...

600343, A61B 500

Patent

active

058205560

DESCRIPTION:

BRIEF SUMMARY
BACKGROUND OF THE INVENTION

1. Field of the Invention
The present invention relates to a method for a primarily ambulatory parameter registeration related to the presence of bilirubin in the gastrointestinal tract.
The invention also relates to a system for performing said method.
2. History of the Related Art
According to the state of art of essentially a fibreoptic means is inserted in the gastrointestinal tract and the light absorption at a wave length of about 460 nm is measured by means of spectrophotography, the wave length being indicated to correspond the maximum bilirubin absorption. Also, the light absorption is measured at a wavelength of 600 nm, being a reference length with a minimal bilirubin related absorption. This technology has been found to possibly provide absorption values for bilirubin containing more than a 10 precent error level or more. Errors in this magnitude are sufficient to make it impossible to distinguish patients with a normal bilirubin exposure in the measuring region of the gastrointestinal tract from patients with an abnormal exposure.


SUMMARY OF THE INVENTION

The present invention relates to a method and a system, with which reliable bilirubin related exposure measurements can be achieved.


BRIEF DESCRIPTION OF THE DRAWINGS

The invention is described here below more in detail with reference to an executed example and the attached drawings, wherein
FIG. 1 illustrates schematically a first embodiment of a system according to the present invention for an ambulatory registration of i.a. the presence of bilirubin in the gastrointestinal tract,
FIG. 2 shows schematically and in more detail a part of the system in FIG. 1, and
FIG. 3 shows schematically the maximum absorption in relation to the pH-value.
In the preferred embodiment of the system shown in FIG. 1 and 2 with 1 is designated a registration unit for the ambulatory measurement and registration adapted to be carried by the patient together with the actual detecting means. Units of this kind are already known. According to a preferred embodiment the registration unit 1 thus comprises a Synectics MicroDigitrapper 2 being descbribed in the european patent No 0,356,603, by which means a plurality of measurement items, i.e. parameters such as a pH-value, can be registered.
The system includes means for the determination of at least one parameter depending on the presence of bilirubin in a measuring region 3 in the gastrointestinal tract 4 of a patient 5. The region is here shown schematically as a container 7 filled with a fluid 6.
For the determination of i.a. the light absorption in the measuring region a catheter 8 is provided adapted to run from the outside of the patient to the measuring region and including fibreoptical conducting means 9 adapted to conduct light by means of at least one light diode 10 or a similarly created light. The present light diodes 10 consist of measuring and control means 11, here illustrated separated from the unit 2, but which preferably are included in the registration unit as schematically illustrated in FIGS. 1 and 2. According to preferred embodiments means are provided in the form of light emitting diodes, fibreoptical conductors, sensor elements 12, etc., principally according to U.S. Pat. No. 4,976,265 to determine the amount of light absorption in the measuring region. The light is of a generally certain first wavelength l.sub.1 corresponding to the maximum bilirubin light absorption in the measuring region and as a reference to determine the amount of light absorption in the measuring region, this light being of a generally certain second wavelength l.sub.0 corresponding to the minimum bilirubin light absorption, schematically shown spectrophotographical means 11' preferably being provided in the measuring and control means to analyze the light from the measuring region.
Furthermore, there are, according to the invention, provided means, e.g. comprising an antimony crystal sensor 13 for measuring the pH-value in the measuring region, the pH-value related measuring values bei

REFERENCES:
patent: 4412005 (1983-10-01), Wu
patent: 4632119 (1986-12-01), Reichstein
patent: 4976265 (1990-12-01), Falcial et al.
patent: 5438985 (1995-08-01), Essen-Moller

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