Method and apparatus for preparation of molded tablet and thereb

Details Method and apparatus for preparation of molded tablet and thereb Method and apparatus for preparation of molded tablet and thereb

1993-09-28

2000-03-14

Harrison, Robert H.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424465, 424466, A61K 920, A61J 310

Patent

active

060369744

ABSTRACT:
Active ingredients such as medicines are mixed with excipient and then kneaded together with binder and solvent such as alcohol or water to prepare a wetted paste. A mold is filled with this paste. Top and bottom surfaces of the paste within the mold are coated with powder such as lubricant in order to avoid possible sticking of the paste to the apparatus during a subsequent compression step. Then a compressive pressure is exerted on the surface of the paste. Thereafter, the tablet is taken from the mold. The molded tablet can contain water-soluble or fat-soluble medicine.

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Ansel, Howard C., Pharmaceutical Dosage Forms and Drug Delivery Systems, 5.sup.th ed., Lea & Febiger, Philadelphia, 1990, p.160.
Remington's Pharmaceutical Sciences, 18.sup.th ed., Mack Publishing Co., Easton, Pa, 1990 pp. 1656-1658.

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