Chemistry: analytical and immunological testing – Optical result – With reagent in absorbent or bibulous substrate
Reexamination Certificate
2007-12-25
2007-12-25
Gakh, Yelena G. (Department: 1743)
Chemistry: analytical and immunological testing
Optical result
With reagent in absorbent or bibulous substrate
C436S164000, C436S166000, C436S169000, C422S051000, C422S051000, C422S051000, C422S082050
Reexamination Certificate
active
10902511
ABSTRACT:
Apparatus for use in effecting surface-enhanced Raman spectroscopy comprises first and second containment means, the first containment means containing a known quantity of a reference chemical having an effective surface-enhanced Raman factor, and the second containment means containing a surface-enhanced Raman-active medium and being sufficiently transparent, at least at one optical access location, to permit both the excitation irradiation of, and also the collection of surface-enhanced Raman scattered radiation from, a common field of view of the surface-enhanced Raman-active medium. The apparatus is constructed for carrying out the method of the invention; i.e., for effecting intimate mixing, substantially prior to introduction to the surface-enhanced Raman-active medium contained in the second containment means, of the reference chemical with an analyte chemical-containing solution introduced through an entrance into the first containment means. The homogeneous test solution so formed permeates the SER-active material in the second containment means, which is irradiated at the common field of view so as to produce SER scattered radiation for collection and quantitative analysis.
REFERENCES:
Cabalin et al. “Flow-injection analysis and liquid chromatography: surface-enhanced Raman spectrometry detection by using windowless flow cell”, Analytica Chimica Acta, 1996.
Cabalin et al. “Surface-enhanced Raman spectrometry for detection in liquid chromatography using a windowless flow cell”, Talanta, 1993, v. 40,, No. 11, pp. 1741-1747, Abstract.
Nirode et al. “On-column surface-enhanced Raman spectroscopy detection in capillary electrophoresis using running buffers containing silver colloidal solutions”, Anal. Chem., 2000, v. 72, pp. 1866-1871.
Farquharson et al. “Simultaneous chemical separation and surface-enhanced Raman spectral detection using silver-doped sol-gels”, Applied Spectroscpy, 2003, . 57, No. 4, pp. 479-481.
Farquharson et al. “Rapid dipicolinic acid extraction fromBacillus sporesdetected by surface-enhanced Raman spectroscopy”, Applied Spectroscopy, 2004, v. 53, No. 3, pp. 351-354.
Dorman Tra S.
Gakh Yelena G.
Real-Time Analyzers, Inc.
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