Measuring and testing – Sampler – sample handling – etc. – Capture device
Patent
1990-02-08
1991-06-18
Raevis, Robert
Measuring and testing
Sampler, sample handling, etc.
Capture device
G01N 114
Patent
active
050241095
ABSTRACT:
This invention provides a method and apparatus for correcting for the hydrostatic dead volume error which may occur in a pipette system and may also include method and apparatus for correcting for a lost fluid volume error. The technique involves determining the height of fluid in the tip for a desired fluid volume, determining the change in the dead volume resulting from having fluid of such height in the tip and determining the piston displacement required to achieve a volume equal to the sum of the desired volume and the determined change in dead volume, this determined displacement being the piston movement required to achieve the desired fluid volume. The height is determined from the volume multiplied by values which are constant for a given tip size and geometry. The change in dead volume varies as a function of the desired fluid height times a constant for a given fluid, pipette system and tip. Where a plurality of fluid samples are in the tip, and at least some of the samples are separated by a gas, the height, dead volume change and piston displacement determinations are made for each measured piston displacement to either intake or dispense. For multiple samples, height determinations for each sample are made utilizing only fluid heights. Where appropriate, a lost fluid volume correction value may also be added to the corrected volume utilized to perform piston displacement calculations.
REFERENCES:
patent: 4821586 (1989-04-01), Scordato et al.
patent: 4896270 (1990-01-01), Kalmakis et al.
patent: 4905526 (1990-03-01), Magnussen, Jr. et al.
Anderson Robert
Romero Hugo
Medical Laboratory Automation, Inc.
Raevis Robert
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