Method and apparatus for optically determining total hemoglobin

Details Method and apparatus for optically determining total hemoglobin Method and apparatus for optically determining total hemoglobin

1998-02-27

2000-08-15

Snay, Jeffrey

Chemical apparatus and process disinfecting, deodorizing, preser

Analyzer, structured indicator, or manipulative laboratory...

Means for analyzing liquid or solid sample

356 39, 356433, 436 68, 436164, G01N 2100

Patent

active

061031976

ABSTRACT:
In a method of optically determining the total hemoglobin concentration (tHb) in non-hemolyzed whole blood, using at least two wavelengths for measuring, a first wavelength of .lambda.<805 nm and a second wavelength of .lambda.>805 nm is employed, such that the following is valid for the absorption coefficients of the hemoglobin derivatives O.sub.2 Hb and RHb at the two measurement wavelengths .lambda..sub.1 and .lambda..sub.2 : .sigma.O(.lambda..sub.1).about..sigma.R(.lambda..sub.2) and .sigma.R(.lambda..sub.1).about..sigma.O(.lambda..sub.2). The sum of absorption values A.sub.1 and A.sub.2 measured at wavelengths .lambda..sub.1 and .lambda..sub.2 will be a quantity which is proportional to the total hemoglobin concentration tHb and independent of the oxygen saturation O.sub.2sat.

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S. Takatani et al. "A Miniature Hybrid Reflection Type Optical Sensor . . . Whole Blood" in IEEE, vol. 35, No. 3, Mar. 1988.
International Patent Publication No. WO 94/08237 to A. Shepherd et al. entitled Method and Apparatus for Direct Spectrophotometric Measurements in Unaltered Whole Blood, dated Apr., 1994.

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