Method and apparatus for on-line filtration removal of macromole

Surgery – Respiratory method or device – Ozone or ion generation

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210434, A61M 500

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active

043501567

ABSTRACT:
An on-line filtration system for the removal of macromolecules greater than 70,000 mol. wt. from a physiological solution, such as blood, in the therapeutic treatment of various disease states. For blood, the plasma (which contains the macromolecules) is separated continuously from the blood using a first membrane filter with a membrane porosity of nominally 0.2 to 1.0 micron. The separated plasma is then continuously filtered in a physiological temperature state or a cooled state through a second membrane filter with a membrane porosity of nominally 0.01 to 0.2 micron, which retains the macromolecules. In the cooled state, separation of the macromolecules is effected more efficiently than could be done in the non-cooled state. The treated plasma (macromolecules removed) is then reunited with the blood flow coming from the first plasma filter and returned to the patient. The blood flow and filtration processes are generally continuous. Suitable agent(s) may be added to the separated plasma to promote formation of macromolecules.

REFERENCES:
patent: 3579441 (1971-05-01), Brown
patent: 3802432 (1974-04-01), Djerassi
patent: 3941356 (1976-03-01), Mason
patent: 4103685 (1978-08-01), Lupien
patent: 4111199 (1978-09-01), Djerassi
patent: 4191182 (1980-03-01), Popovich
patent: 4215688 (1980-08-01), Terman
patent: 4223672 (1980-09-01), Terman
patent: 4243532 (1981-01-01), Tsuda
New Zealand Medical Journal, vol. 92, No. 666, 8-27-1980, pp. 145-148.
Plasmapheresis Therapy of Immunologic Disease--from Cleveland Clinic Quarterly, vol. 47, No. 2, 1980, pp. 53-72.

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