Method and apparatus for NMR spectroscopy of nanoliter volume sa

Electricity: measuring and testing – Particle precession resonance – Spectrometer components

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324307, G01R 3346

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056546360

ABSTRACT:
A method and apparatus for structural elucidation and determination of a nanoliter size sample of analyte. The method includes separating the analyte using a microseparation technique and then substantially simultaneously analyzing or detecting the sample using a nuclear magnetic resonance (NMR) spectrometer. The apparatus includes an RF microcoil positioned for operable communication with a capillary member of the microseparation system and the NMR spectrometer to provide enhanced sensitivity and improved signal-to-noise ratio of the NMR spectrometer necessary to accurately analyze or detect nanoliter size samples.

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