Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...
Reexamination Certificate
2007-08-07
2007-08-07
Winakur, Eric F. (Department: 3768)
Surgery
Diagnostic testing
Measuring or detecting nonradioactive constituent of body...
Reexamination Certificate
active
10916236
ABSTRACT:
In accordance with the invention, a low coherence interferometer is used to non-invasively monitor the concentration of glucose in blood by shining a light over a surface area of human or animal tissue, continuously scanning the light over a two dimensional area of the surface, collecting the reflected light from within the tissue and constructively interfering this reflected light with light reflected along a reference path to scan the tissue in depth. Since the reflection spectrum is sensitive to glucose concentration at particular wavelengths, measurement and analysis of the reflected light provides a measure of the level of glucose in the blood. The measurement of glucose is taken from multiple depths within blood-profused tissue, and sensitivity is preferably enhanced by the use of multiple wavelengths. Noise or speckle associated with this technique is minimized by continuously scanning the illuminated tissue in area and depth.
REFERENCES:
patent: 3826905 (1974-07-01), Valkama et al.
patent: 3958560 (1976-05-01), March
patent: 4014321 (1977-03-01), March
patent: 4476875 (1984-10-01), Nilsson et al.
patent: 4590948 (1986-05-01), Nilsson
patent: 4606351 (1986-08-01), Lübbers
patent: 4655225 (1987-04-01), Dähne et al.
patent: 4704029 (1987-11-01), Van Heuvelen
patent: 4731363 (1988-03-01), Hamilton et al.
patent: 4750830 (1988-06-01), Lee
patent: 4834111 (1989-05-01), Khanna et al.
patent: 4871755 (1989-10-01), Alig et al.
patent: 4873989 (1989-10-01), Einzig
patent: 4882492 (1989-11-01), Schlager
patent: 4883953 (1989-11-01), Koashi et al.
patent: 4890621 (1990-01-01), Hakky
patent: 4901728 (1990-02-01), Hutchinson
patent: 4948248 (1990-08-01), Lehman
patent: 4979509 (1990-12-01), Hakky
patent: 4989978 (1991-02-01), Groner
patent: 5025785 (1991-06-01), Weiss
patent: 5028787 (1991-07-01), Rosenthal et al.
patent: 5054487 (1991-10-01), Clarke
patent: 5070874 (1991-12-01), Barnes et al.
patent: 5101814 (1992-04-01), Palti
patent: 5112124 (1992-05-01), Harjunmaa et al.
patent: 5115133 (1992-05-01), Knudson
patent: 5168325 (1992-12-01), Yoder-Short
patent: 5178153 (1993-01-01), Einzig
patent: 5209231 (1993-05-01), Cote et al.
patent: 5222495 (1993-06-01), Clarke et al.
patent: 5222496 (1993-06-01), Clarke et al.
patent: 5243983 (1993-09-01), Tarr et al.
patent: 5267152 (1993-11-01), Yang et al.
patent: 5277181 (1994-01-01), Mendelson et al.
patent: 5313941 (1994-05-01), Braig et al.
patent: 5321501 (1994-06-01), Swanson et al.
patent: 5341805 (1994-08-01), Stavridi et al.
patent: 5348003 (1994-09-01), Caro
patent: 5349953 (1994-09-01), McCarthy et al.
patent: 5361758 (1994-11-01), Hall et al.
patent: 5370114 (1994-12-01), Wong et al.
patent: 5376336 (1994-12-01), Lübbers et al.
patent: 5379238 (1995-01-01), Stark
patent: 5383452 (1995-01-01), Buchert
patent: 5398681 (1995-03-01), Kupershmidt
patent: 5433197 (1995-07-01), Stark
patent: 5435309 (1995-07-01), Thomas et al.
patent: 5448992 (1995-09-01), Kupershmidt
patent: 5452716 (1995-09-01), Clift
patent: 5457535 (1995-10-01), Schmidtke et al.
patent: 5459570 (1995-10-01), Swanson et al.
patent: 5492118 (1996-02-01), Gratton et al.
patent: 5501226 (1996-03-01), Petersen et al.
patent: 5535743 (1996-07-01), Backhaus et al.
patent: 5549114 (1996-08-01), Petersen et al.
patent: 5551422 (1996-09-01), Simonsen et al.
patent: 5553616 (1996-09-01), Ham et al.
patent: 5582168 (1996-12-01), Samuels et al.
patent: 5710630 (1998-01-01), Essenpreis et al.
patent: 5795295 (1998-08-01), Hellmuth et al.
patent: 6036919 (2000-03-01), Thym et al.
patent: 6147108 (2000-11-01), Hauptman
patent: 6294062 (2001-09-01), Buck, Jr. et al.
patent: 6425863 (2002-07-01), Werner et al.
patent: 6443881 (2002-09-01), Finger
patent: 6541216 (2003-04-01), Wilsey et al.
patent: 6544212 (2003-04-01), Galley et al.
patent: 6556853 (2003-04-01), Cabib et al.
patent: 6572566 (2003-06-01), Effenhauser
patent: 6707554 (2004-03-01), Miltner et al.
patent: 6725073 (2004-04-01), Motamedi et al.
patent: 6780651 (2004-08-01), Douglas et al.
patent: 6836337 (2004-12-01), Cornsweet
patent: 6837337 (2005-01-01), Thomas et al.
patent: 6990364 (2006-01-01), Ruchti et al.
patent: 2002/0016533 (2002-02-01), Marchitto et al.
patent: 0282234 (1988-09-01), None
patent: 0160768 (1989-05-01), None
patent: 0127947 (1990-08-01), None
patent: 0280986 (1992-07-01), None
patent: 0317121 (1994-02-01), None
patent: 0536187 (1994-09-01), None
patent: 0589191 (1997-03-01), None
patent: 0603658 (1999-02-01), None
patent: 0631137 (2002-03-01), None
patent: 0670143 (2003-05-01), None
patent: WO 88/06726 (1988-09-01), None
patent: WO 89/10087 (1989-11-01), None
patent: WO 91/18548 (1991-12-01), None
patent: WO 92/10131 (1992-06-01), None
patent: WO 92/17765 (1992-10-01), None
patent: WO 93/00855 (1993-01-01), None
patent: WO 93/07801 (1993-04-01), None
patent: WO 93/09421 (1993-05-01), None
patent: WO 93/16629 (1993-09-01), None
patent: WO 94/04070 (1994-03-01), None
patent: WO 94/13193 (1994-06-01), None
patent: WO 95/32416 (1995-11-01), None
patent: WO 02/065090 (2002-08-01), None
Arnold, M.A., et al, “Determination of Physiological Levels of Glucose in an Aqueous Matrix with Digitally Filtered Fourier Transform Near-infrared Spectra,” Anal. Chem., vol. 64, No. 14, pp. 1457-1464 (1990).
Arnold, V.W., “Fourier transformation infrared spectrometry—a new (old) method of detection in forensic chemistry and criminal investigation,” Beitr Gerichtl Med., vol. 47, pp. 123-147 (1989).
Bruulsema, J. T., “Correlation between blood glucose concentration in diabetics and noninvasively measured tissue optical scattering coefficient,” Opt. Lett., vol. 22, No. 3, pp. 190-193 (1997).
Burritt, M.F., “Current analytical approaches to measuring blood analytes,” Clin. Chem., vol. 36, No. 8 Pt. 2, pp. 1562-1566 (1990).
Chira, I.S. et al, “Light scattering by blood components after supplying glucose,” Biomed. Tech., vol. 35, No. 5, pp. 102-106 (1990).
Christison, G.B., et al, “Laser photoacoustic determination of physiological glucose concentrations in human whole blood,” Med. Biol. Eng. Comput., vol. 31, No. 3, pp. 284-290 (1993).
Cote, G. L., et al, “Noninvasive optical polarimetric glucose sensing using a true phase measurement technique,” IEEE Trans. Biomed. Eng., vol. 39, No. 7, pp. 752-756 (1992).
Drezek, R., et al, “Light scattering from cell: finite-difference time-domain simulations and goniometric measurements,” Appl. Opt., vol. 38, No. 16, pp. 3651-3661 (1999).
Duck, F. A., Physical Properties of Tissue, (Academic London 1990).
Dyer, D. G., et al, “Accumulation of Maillard Reaction Products in Skin Collagen in Diabetes and Aging,” J. Clin. Invest., vol. 91, pp. 2463-2469 (1993).
Faber, D. J., et al, “Light absorption of (oxy-) hemoglobin assessed by spectroscopic optical coherence tomography,” Optics Letters, vol. 28, No. 16, pp. 1436-1438 (Aug. 15, 2003).
Fercher, A., et al, “In vivo optical coherence tomography,” Amer. J. Opthalmol., vol. 116, No. 1, pp. 113-114 (1993).
Flock, S.T., et al, “Total attenuation coefficients and scattering phase functions of tissues and phantom materials at 633 nm,” Med. Phys., vol. 14, No. 5, pp. 835-841 (1987).
Fogt, E.J., “Continuous ex vivo and in vivo monitoring with chemical sensors,” Clin. Chem., vol. 36, No. 8 Pt. 2, pp. 1573-1580 (1990).
Frank, K.H., et al, “Measurements of angular distributions of Rayleigh and Mie scattering events in biological models,” Phys. Med. Biol., vol. 34, No. 8, pp. 1901-1916 (1989).
Gabriely, I., et al, “Transcutaneous glucose measurement using near-infrared spectroscopy during hypoglycemia,” Diabetes Care, vol. 22, No. 12, pp. 2026-2032 (1999).
Galanzha, E. I., et al, “Skin backreflectance and microvascular system functioning at the action of osmotic agents,” J. Phys. D. Appl. Phys., vol. 36, pp. 1739-1746 (2003).
Gilbert, J.W., et al, “A cerebrospinal fluid glucose biosensor for diabetes
Schurman Matthew J.
Shakespeare Walter J.
Engellenner Thomas J.
GlucoLight Corporation
Nutter & McClennen & Fish LLP
Shen Charlton
Winakur Eric F.
LandOfFree
Method and apparatus for monitoring glucose levels in a... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for monitoring glucose levels in a..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for monitoring glucose levels in a... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3897641