Method and apparatus for measuring cell-by-cell hemoglobin

Optics: measuring and testing – Blood analysis – Hemoglobin concentration

Reexamination Certificate

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C356S039000

Reexamination Certificate

active

07095492

ABSTRACT:
An apparatus and method for directly determining the hemoglobin content (CH) of individual sphered red blood cells and for directly determining the width of the cell hemoglobin distribution of a red blood cell sample. Such apparatus and method monitors the light reflected by individual sphered cells as they are made to pass through an optical flow cell while being irradiated by a suitable source of radiation.

REFERENCES:
patent: 4711852 (1987-12-01), Jacobson et al.
patent: 4735504 (1988-04-01), Tycko
patent: 5194909 (1993-03-01), Tycko
patent: 5492833 (1996-02-01), Rodriguez et al.
patent: 6228652 (2001-05-01), Rodriguez et al.
patent: 6393310 (2002-05-01), Kuenstner
patent: 6869569 (2005-03-01), Kramer
patent: 2001/0024800 (2001-09-01), Garcia-Rubio et al.
patent: 2003/0030783 (2003-02-01), Roche et al.
patent: 2004/0038413 (2004-02-01), Kramer
Tycko, D.H., et al., “Flow-cytometric light scattering measurement of red blood cell volume and hemoglobin concentration”,Applied Optics,vol. 24, No. 9, pp. 1355-1365, May 1, 1985.

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