Method and apparatus for mass spectrometry analysis of...

Radiant energy – Ionic separation or analysis – With sample supply means

Reexamination Certificate

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C250S286000, C250S281000, C250S282000, C250S343000, C073S863110, C073S863120

Reexamination Certificate

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06943346

ABSTRACT:
An apparatus and method for generating ions from an aerosol and transferring the ions into a mass analyzer. In the apparatus and method, an aerosol beam is generated, the aerosol beam is directed to a spatial volume outside the mass analyzer, particles in the aerosol beam are ionized to produce the ions, and the ions are collected into the mass analyzer. As such the apparatus includes respectively an aerosol beam generator, an ion source generator, and an ion collector.

REFERENCES:
patent: 4924097 (1990-05-01), Browner et al.
patent: 5285064 (1994-02-01), Willoughby
patent: 5498545 (1996-03-01), Vestal
patent: 5917185 (1999-06-01), Yeung et al.
patent: 5965884 (1999-10-01), Laiko et al.
patent: 6175112 (2001-01-01), Karger et al.
patent: 6797945 (2004-09-01), Berggren et al.
patent: 2002/0158196 (2002-10-01), Berggren et al.
patent: 2002/0166961 (2002-11-01), Berggren et al.
patent: 1193730 (2002-04-01), None
Michael Karas et al., Laser Desorption Ionization of Proteins with Molecular Masses Exceeding 10 000 Daltons, Anal. Chem. Oct. 15, 1988, vol. 60, pp. 2299-2301.
John B. Fenn et al., Electrospray Ionization for Mass Spectrometry of Large Biomolecules, Science, Oct. 6, 1989, vol. 246, pp. 64-71.
Kermit K. Murrary, Coupling Matrix-Assisted Laser Desorption/Ionization to Liquid Separations, Mass Spectrometry Reviews, 1997, vol. 16, pp. 283-299.
Henrik Orsnes et al, Interfaces for On-line Liquid Sample Delivery For Matrix-Assisted Laser Desorption Ionization Mass Spectrometry, Chem. Soc. Rev., 2001, vol. 30, pp. 104-112.
Frantisek Foret et al., Liquid Phase Interfacing and Miniaturization in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Proteomics 2002, vol. 2, pp. 360-372.
Victor V. Laiko et al., Desorption/Ionization of Biomolecules from Aqueous Solutions at Atmospheric Pressure Using an Infrared Laser at 3 μm, J. Am. Soc. for Mass Spectrom 2002, vol. 13, pp. 354-361.
Kermit K. Murray et al, Aerosol Matrix-Assisted Laser Desorption Ionization for Liquid Chromatography/Time-of-Flight Mass Spectrometry, Anal. Chem. 1994, vol. 66, pp. 1601-1609.
Bashir A. Mansoori et al., Matrix-Assisted Laser Desorption/Ionization of Size- and Composition-Selected Aerosol Particles, Anal. Chem. 1996, vol. 68, pp. 3595-3601.
Lin He et al., 337 nm Matrix-Assisted Laser Desorption/Ionization of Single Aerosol Particles, Journal of Mass Spectrometry 1999 vol. 34, pp. 909-914.
Peng Liu et al, Generating Particle Beams of Controlled Dimensions and Divergence: II. Experimental Evaluation of particle Motion in Aerodynamic Lenses and Nozzle Expansions, Aerosol Science and Technology 1995 vol. 22, pp. 314-324.
Paul J. Galley et al., Technique for Producing Capillaries with Reproducible Orifice Diameters for Uniform Droplet Generation, Applied Spectroscopy, 1992, vol. 46, No. 10, pp. 1460-1463.
Feng et al., Single Isolated Droplets With Net Charge as a Source of Ions, J. Am. Soc. Mass Spectrom 2000, vol. 11, pp. 393-399.
G. Allmaier, Picoliter to Nanoliter Deposition of Peptide and Protein Solutions for Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry, Rapid Communications in Mass Spectrometry, 1997 vol. 11, pp. 1567-1569.
David Ericsson et al., Downsizing Proteolytic Digestion and Analysis Using Dispenser-Aided Sample Handling and Nanovial Matrix-Assisted Laser/Desorption Ionization-Target Arrays, Proteomics 2001, vol. 1, pp. 1072-1081.
Daniel P. Little et al., MALDI on a Chip: Analysis of Arrays of Low-Femtomole to Subfemtomole Quantities of Synthetic Oligonucleotides and DNA Diagnostic Products Dispensed by a Piezoelectric Pipet, Anal. Chem. 1997, vol. 69, pp. 4540-4546.
Koichi Tanaka et al., Protein and Polymer Analyses up to m/z 100 000 by Laser Ionization Time-of-flight Mass Spectrometry, Rapid Communications in Mass Spectrometry, vol. 2, No. 8, 1988, pp. 151-153.

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