Method and apparatus for mass spectrometric analysis

Details Method and apparatus for mass spectrometric analysis Method and apparatus for mass spectrometric analysis

2011-01-04

2011-01-04

Berman, Jack I (Department: 2881)

Radiant energy

Ionic separation or analysis

With sample supply means

C250S281000, C250S282000

Reexamination Certificate

active

07863559

ABSTRACT:
A method and an apparatus for examining a sample by means of mass spectrometry. According to the method, the solution comprising the sample to be examined is vaporized in a vaporizer, the vaporized sample solution is sprayed, using a gas flow, into a corona discharge zone, where the examined sample is ionised according to the APCI method, using a corona discharge, to generate gas phase ions, and the ions are separated and directed to a detector. According to the present invention, a vaporizer is used, which is fabricated as a micromechanical structure which comprises the flow channels for the solution and for the carrier gas possibly used for feeding the solution, as well as the heater of the vaporizer, and which are all included in a monolithic structure. The solution is especially suitable for cases in which a very sensitive analysing technique is needed, or in which the available sample quantity is very small (less than 1 μL).

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Daniel D. Ebeling, Michael S. Westphall, Mark Scalf, and Lloyd M. Smith, “Corona Discharge in Charge Reduction Electrospray Mass Spectrometry”, Analytical Chemistry, vol. 72, No. 21, Nov. 1, 2000, pp. 2-5.
Office Action issued Jul. 6, 2010 by Japanese Patent Office in counterpart Japanese Application No. 2006-538878.

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