Method and apparatus for manufacturing beads array chip

Chemical apparatus and process disinfecting – deodorizing – preser – Control element responsive to a sensed operating condition

Reexamination Certificate

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C422S063000, C422S065000, C422S091000, C422S105000, C436S054000, C436S180000

Reexamination Certificate

active

07820112

ABSTRACT:
A bead array chip manufacturing process for manufacturing a bead array chip having plural kinds of beads arrayed in a predetermined order in, in a container having a plurality of first channels disposed substantially in parallel with each other and a second channel crossing the plurality of first channels, each of the first channels. The process including lowering a capillary inserted in the second channel and sucking and retaining one bead in one end of the capillary, lifting the capillary to position the beads retained in the one end of the capillary in a desired channel of the plurality of first channels, terminating the suction of the capillary, and generating a uniflow of a fluid in the second channel.

REFERENCES:
patent: 6497155 (2002-12-01), Feygin et al.
patent: 11-243997 (1999-09-01), None
patent: 2000-346842 (2000-12-01), None
“Light-Directed, Spatially Addressable Parallel Chemical Synthesis” by Stephen Fodor, et al. pp. 767-773.
Science vol. 270. Oct. 20, 1995 pp. 467-470.
Nature Biotechnology vol. 18, 2000. “Microarray fabrication with colvalent attachment of DNA using Bubble Jet technology”, pp. 438-441.
Clinical Chemistry, vol. 43, pp. 1749-1756, (1997) “Advance multiplexed analysis with the Flow Metrix system”.
Science, vol. 287. pp. 451-452 (2000).
“DNA probes on beads arrayed in a capillary, ‘Bead-array’, exhibited high hybridization perform”, Nucleic Acids Research, 2002, vol. 30 No. 16. pp. 1-7.

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