Method and apparatus for manufacturing beads array chip

Details Method and apparatus for manufacturing beads array chip Method and apparatus for manufacturing beads array chip

2004-03-01

2008-11-04

Warden, Jill (Department: 1797)

Chemical apparatus and process disinfecting, deodorizing, preser

Control element responsive to a sensed operating condition

C422S063000, C422S064000, C422S065000, C422S091000, C422S105000, C436S054000, C436S180000

Reexamination Certificate

active

07445755

ABSTRACT:
Provided is a convenient process of manufacturing a two-dimensional bead array on a chip by disposing a plurality of beads immobilized with a biomolecular probe in a bead array container in a predetermined order. The bead array chip is manufactured by repeating the following operations: a container having a plurality of first channels disposed in parallel with each other and a second channel crossing therewith is retained in a container retaining portion and a capillary is moved through the second channel of the container vertically. The capillary is moved downward to suck and retain, in an end thereof, one bead stored in a storing portion of a bead storing plate and then, moved upward to the position of a desired first channel. Under this state, pure water is fed to the first passage from a water feed system and a water stream is generated by sucking the pure water by a suction pump. The bead retained in the end of the capillary is transferred by the water stream and is then, blocked by a dam disposed in the first channel, in which the bead is retained.

REFERENCES:
patent: 11-243997 (1999-09-01), None
patent: 2000-346842 (2000-12-01), None
“Light-Directed, Spatially Addressable Parallel Chemical Synthesis” by Stephen Fodor, et al. pp. 767-773.
Science vol. 270. Oct. 20, 1995 pp. 467-470.
Nature Biotechnology vol. 18, 2000. “Microarray fabrication with colvalent attachment of DNA using Bubble Jet technology”, pp. 438-441.
Clinical Chemistry, vol. 43, pp. 1749-1756, (1997) “Advance multiplexed analysis with the Flow Metrix system”.
Science, vol. 287. pp. 451-452 (2000).
“DNA probes on beads arrayed in a capillary, ‘Bead-array’, exhibited high hybridization perform”, Nucleic Acids Research, 2002, vol. 30 No. 16. pp. 1-7.

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