Chemistry: molecular biology and microbiology – Treatment of micro-organisms or enzymes with electrical or... – Cell membrane or cell surface is target
Reexamination Certificate
2006-03-28
2006-03-28
Witz, Jean C. (Department: 1651)
Chemistry: molecular biology and microbiology
Treatment of micro-organisms or enzymes with electrical or...
Cell membrane or cell surface is target
C435S450000, C435S461000
Reexamination Certificate
active
07018819
ABSTRACT:
An apparatus and method are disclosed for electromanipulation of at least one cell or cell-like structure having cell-like membranes, the method comprising the steps: (a) at least one cell or cell-like structure is transported from one or more sample containers located on a chip through microchannel(s) located on said chip into a chamber located on said chip, wherein said chamber contains electrode(s) connected to a voltage generator, wherein said microchannel provides a fluid contact between the sample containers, (b) said cell or cell-like structure(s) is placed close to said at least one electrode, and (c) an electrical field is applied and focused on said cell or cell-like structure(s), said electrical field being of a strength sufficient to obtain pore-formation or fusion of said at least one cell or cell-like structure with another cell or cell-like structure(s) present in said chamber.
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Microfluidic Device for Combinatorial Fusion of Liposomes and Cells, Anette Strömberg, et al., Department of Chemistry, Göteborg University, S-412 96, Göteborg, Sweden, Analytical Chemistry, Reprinted from vol. 73, No. 1, pp. 126-130, Jan. 1, 2001.
Chiu Daniel
Karlsson Anders
Karlsson Mattias
Orwar Owe
Stromberg Anette
Cellectricon AB
Conlin David G.
Edwards & Angell LLP
Hanley Susan
Patton Stephana E.
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