Method and apparatus for manipulating an organic liquid sample

Details Method and apparatus for manipulating an organic liquid sample Method and apparatus for manipulating an organic liquid sample

2004-07-16

2008-05-20

Ciric, Ljiljana (Department: 3744)

Heat exchange

With timer, programmer, time delay, or condition responsive...

C165S269000, C422S109000, C422S127000, C435S286100, C435S288300, C435S288400, C435S305300

Reexamination Certificate

active

07373968

ABSTRACT:
A lid for a well plate, which has pins that penetrate the lid and project downwardly into the wells of the well plate. Thermal energy is applied to the upper end of the pin to regulate the temperature of liquid samples. Ultrasonic energy is applied to the upper end of the pin to sonicate the liquid sample. An electrical charge is applied to the upper end of the pin to attract charged materials, such as DNA, and to selectably segregate charged materials from the liquid sample.

REFERENCES:
patent: 1006787 (1911-10-01), Pratt
patent: 1456005 (1923-05-01), Harris
patent: 2379474 (1945-07-01), Bramson
patent: 3379118 (1968-04-01), Perez
patent: 3616264 (1971-10-01), Ray et al.
patent: 4038055 (1977-07-01), Varano et al.
patent: 4116777 (1978-09-01), Takátsy et al.
patent: 4286456 (1981-09-01), Sisti et al.
patent: 4420679 (1983-12-01), Howe
patent: 4468423 (1984-08-01), Hall
patent: 4481405 (1984-11-01), Malick
patent: 4683195 (1987-07-01), Mullis et al.
patent: 4683202 (1987-07-01), Mullis
patent: 4687636 (1987-08-01), Hart
patent: 4701415 (1987-10-01), Dutton et al.
patent: 4827780 (1989-05-01), Sarrine et al.
patent: 4865986 (1989-09-01), Coy et al.
patent: 4889818 (1989-12-01), Gelfand et al.
patent: 4891321 (1990-01-01), Hubscher
patent: 4902624 (1990-02-01), Columbus et al.
patent: 4965188 (1990-10-01), Mullis et al.
patent: 4981801 (1991-01-01), Suzuki et al.
patent: 5038852 (1991-08-01), Johnson et al.
patent: 5061630 (1991-10-01), Knopf et al.
patent: 5200084 (1993-04-01), Liberti et al.
patent: 5236666 (1993-08-01), Hulette et al.
patent: 5333675 (1994-08-01), Mullis et al.
patent: 5432086 (1995-07-01), Frä{umlaut over ( )}nzl et al.
patent: 5455175 (1995-10-01), Wittwer et al.
patent: 5489532 (1996-02-01), Charm et al.
patent: 5525300 (1996-06-01), Danssaert et al.
patent: 5601141 (1997-02-01), Gordon et al.
patent: 5602756 (1997-02-01), Atwood et al.
patent: 5604130 (1997-02-01), Warner et al.
patent: 5681492 (1997-10-01), Van Praet
patent: 5716842 (1998-02-01), Baier et al.
patent: 5721136 (1998-02-01), Finney et al.
patent: 5770151 (1998-06-01), Roach et al.
patent: 5819842 (1998-10-01), Potter et al.
patent: 5863507 (1999-01-01), James
patent: 5939312 (1999-08-01), Baier et al.
patent: 6083763 (2000-07-01), Balch
patent: 6086821 (2000-07-01), Lee
patent: 6101946 (2000-08-01), Martinsky
patent: 6153426 (2000-11-01), Heimberg
patent: 6171850 (2001-01-01), Nagle et al.
patent: 6197575 (2001-03-01), Griffith et al.
patent: 6207369 (2001-03-01), Wohlstadter et al.
patent: 6277332 (2001-08-01), Sucholeiki
patent: 6312960 (2001-11-01), Balch et al.
patent: 6331441 (2001-12-01), Balch et al.
patent: 6338802 (2002-01-01), Bodner et al.
patent: 6372486 (2002-04-01), Fripp
patent: 6423536 (2002-07-01), Jovanovich et al.
patent: 6451261 (2002-09-01), Bodner et al.
patent: 6479301 (2002-11-01), Balch et al.
patent: 6489112 (2002-12-01), Hadd et al.
patent: 6627421 (2003-09-01), Unger et al.
patent: 6640891 (2003-11-01), Oldenburg
patent: 6948843 (2005-09-01), Laugharn, Jr. et al.
patent: 7025120 (2006-04-01), Oldenburg
Cao, T., “A simple and inexpensive system to amplify DNA by PCR,”Biotechniques, 7(6):566-7, Jun. 1989.
Chapin, K., et al., “Evaluation of a rapid air thermal cycler for detection of Mycobacterium tuberculosis,”J. Clin Microbiol., 35(8):2157-9, Aug. 1997.
Civitello, A., et al., “A simple protocol for the automation of DNA cycle sequencing reactions and polymerase chain reactions,”DNA Seq., 3(1):17-23, 1992.
Constants, A., “Some like it hot: A thermal cycler roundup,” The Scientist, 15(24):32, Dec. 10, 2001, pp. 1-7.
Denton, et al.,PCR Protocols: A Guide to Methods and Applications, “A Low-Cost Air Driven Cycling Oven,” pp. 435-441.
Mai,M., et al., “Shortened PCR cycles in a conventional thermal cycler,”Biotechniques, 25(2):208-10, Aug. 1998.
Merriam-Webster's Collegiate Dictionary, Tenth Edition, Merrimam-Webster, Incorporated, 1996, p. 959.
Perry and Green,Perry's Chemical Engineer's Handbook 7thEd., “Heat Transfer by Radiation,” pp. 5-23 to 5-42.
Soper,S., et al., “Sanger DNA-sequencing reactions performed in a solid-pahse nanoreactor directly coupled to capillary gel electrophoresis,”Anal Chem., 70(19):4036-43, Oct. 1, 1998.
Tret'iaov, A., et al., “Fast DNA amplification in smalll ultrthin-wall microplates,”Bioorg Khim., 23(6):526-8, Jun. 1997.
Weis, J., et al., “Detection of rare mRNAs via quantitative RT-PCR,”Trends Genet., 8(8):263-4, Aug. 1992.
Wilding, p., et al., “PCR in a silicon microstructure,”Clin Chem., 40(9):1815-8, Sep. 1994.
Wittwer, C., et al., “Minimizing the time required for DNA amplification by efficient heat transfer to small samples,”Anal Biochem, 86(2):328-31, May 1, 1990.
Wittwer, C., et al., “Rapid cycle DNA amplification: time and temperature optimization,”Biotechniques, 10(1):76-83, Jan. 1991.

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