Plastic article or earthenware shaping or treating: apparatus – Means making particulate material directly from liquid or... – By means applying fluid jet or blast to unconfined liquid...
Reexamination Certificate
2011-07-26
2011-07-26
Del Sole, Joseph S (Department: 1743)
Plastic article or earthenware shaping or treating: apparatus
Means making particulate material directly from liquid or...
By means applying fluid jet or blast to unconfined liquid...
C425S006000, C425S008000, C425S010000, C425S086000, C425S145000, C264S005000, C264S009000, C264S013000, C264S014000, C424S489000
Reexamination Certificate
active
07985058
ABSTRACT:
A method and apparatus for making substantially uniformly sized liposomes and other small particles are provided. Droplets of a first liquid are ejected into a laminar flow of a second liquid, each droplet having a volume of from 0.97V to 1.03V, where V is the mean droplet volume and 1 fL≦V≦50 nL, wherein the first and second liquids are no more than sparingly soluble in one another, and wherein the first liquid contains a solute dissolved, dispersed, or suspended therein; and the first liquid is then removed to form a plurality of substantially uniformly sized particles. In one embodiment, the apparatus includes liquid inlet and outlet channels, a plurality of transverse liquid channels extending from the liquid inlet to the liquid outlet channel, a plurality of nozzles in liquid flow communication with the plurality of transverse liquid channels, one or more nozzle actuators coupled to the plurality of nozzles, and an evaporator coupled to the liquid outlet channel.
REFERENCES:
patent: 2428911 (1947-10-01), Gunnell
patent: 2436439 (1948-02-01), Lincoln et al.
patent: 3885940 (1975-05-01), Levecque et al.
patent: 3962383 (1976-06-01), Hagiwara et al.
patent: 4268293 (1981-05-01), Levecque et al.
patent: 4323455 (1982-04-01), Tanaka et al.
patent: 4481157 (1984-11-01), Morishita et al.
patent: 4661458 (1987-04-01), Berry et al.
patent: 4692284 (1987-09-01), Braden
patent: 4764317 (1988-08-01), Anderson et al.
patent: 4814274 (1989-03-01), Shioya et al.
patent: 4902450 (1990-02-01), Morrison
patent: 5000887 (1991-03-01), Tenzel et al.
patent: 5040960 (1991-08-01), Shioya et al.
patent: 5260002 (1993-11-01), Wang
patent: 5540936 (1996-07-01), Coe et al.
patent: 5653996 (1997-08-01), Hsu
patent: 5741478 (1998-04-01), Osborne et al.
patent: 6103271 (2000-08-01), Morrison et al.
patent: 6217849 (2001-04-01), Tournier et al.
patent: 6258858 (2001-07-01), Nakajima et al.
patent: 6281254 (2001-08-01), Nakajima et al.
patent: 6331314 (2001-12-01), Klinksiek et al.
patent: 6534018 (2003-03-01), Baker et al.
patent: 6572893 (2003-06-01), Gordon et al.
patent: 6576023 (2003-06-01), Nakajima et al.
patent: 6623671 (2003-09-01), Coe et al.
patent: 6689464 (2004-02-01), Lanze et al.
patent: 6855277 (2005-02-01), Baker et al.
patent: 6855296 (2005-02-01), Baker et al.
patent: 6998074 (2006-02-01), Radulescu
patent: 7083572 (2006-08-01), Unger et al.
patent: 7268167 (2007-09-01), Higuchi et al.
patent: 7432110 (2008-10-01), Kikuchi et al.
patent: 2001/0006689 (2001-07-01), Ishikawa et al.
patent: 2002/0050660 (2002-05-01), Coe et al.
patent: 2003/0094715 (2003-05-01), Suzuki et al.
patent: 2003/0124033 (2003-07-01), Baker et al.
patent: 2003/0215514 (2003-11-01), Platz et al.
patent: 2004/0081689 (2004-04-01), Dunfield et al.
patent: 2005/0163723 (2005-07-01), Foster et al.
patent: 2006/0240093 (2006-10-01), MacLachlan et al.
patent: 2007/0034568 (2007-02-01), Foster et al.
patent: 2007/0228588 (2007-10-01), Noritomi et al.
patent: 2008/0061463 (2008-03-01), Guillot et al.
patent: 2008/0171078 (2008-07-01), Gray
patent: 2010/0025872 (2010-02-01), Hashiba
patent: WO2008/089112 (2008-07-01), None
Avestin Applications, website printout from http://avestin.com/efapplications.html; May 30, 2006, 3 pages.
Avanti Polar Lipids, Inc.; product listing from website: http://www.avantilipids.com/extruder.html; Mar. 5, 2004; 3 pages.
Rand;Structural Parameters of Aqueous Phospholipid Mixture; website printout from http://aqueous.labs.brocku.ca/lipid/; Membrane Biophysics Laboratory, St. Catharine's, Ontario, Canada; Feb. 14, 2004; 11 pages.
Souza et al.;Liposome Stability Verification by Atomic Force Microscopy; Rev. Adv. Mater.Sci.5 (2003) 34-40, 7 pages.
Lipid Bilayers and Cell Membranes; excerpt from University of Chicago website http://www.uic.edu/classes/phys/phys461/phys450/MARKO/N016.html; Jun. 29, 2005, 7 pages.
Liposomes and Vesicles, AFM Imaging as a Tool to Visualize Liposomes and Vesicles; PSIA, Inc. website article, www.psiainc.com; Jun. 2005; 11 pages.
Keller, et al.;Thermodynamic Aspects and Biological Profile of CDAN/DOPE and DC-Chol/DOPE Lipoplexes; Research Article; American Chemical Society; Dec. 2002 and Jan. 2003; 11 pages.
Tagawa, et al.;Characterszation of LMD Virus-like Nanoparticles Self-assembled From Cationic Liposomes, Adenovirus Core Peptide μ(mu)Plasmid DNA; Research Article; Gene Therapy, vol. 9 (2002); 564-576; 13 pages.
Alhaique, et al.;Solvent1H NMRD Study of Biotinylated Paramagnetic Liposomes Containing Gd-bis-SDA-DTPA or Gd-DMPE-DTPA; Research Article; F. Inorganica Chimica Acta 331 (2002) 151-157; 7 pages.
Fellowes, et al.;Amelioration of Established Collagen Induced Arthritis by Systemic IL-10 Gene Delivery; Research Article; Gene Therapy, vol. 7 (2000); 967-977; 11 pages.
Thurston, et al.;Cationic Liposomes Target Angiogenic Endothelial Cells in Tumors and Chronic Inflammation in Mice; Research Article; The American Society for Clinical Investigation, Inc., vol. 101, No. 7, Apr. 1998; 1401-1413; 13 pages.
Hainfeld;Gold Liposomes; Research Paper/ web-page article: www.nanoprobes.com/MSA96LIP.html; Department of Biology, Brookhaven National Laboratory, Upton, NY; May 23, 2003; 3 pages.
Goins et al.;The Use of Scintigraphic Imaging as a Tool in the Development of Liposome Formulations; Research Article; Progress in Lipid Research Jan.-Mar. 2001;40(1-2):95-123; 29 pages.
Alhaique, et al.;Solvent1H NMRD Study of Biotinylated Paramagnetic Liposomes Containing Gd-bis-SDA-DTPA or Gd-DMPE-DTPA; Research Article; F. Inorganica Chimica Acta 331 (2002) 151-157; 7 pages.
Singh, et al.;Fluorescent Liposome Flow Markers for Microscale Particle-Image Velocimetry; Research Article; Anal. Chem., (2001), 73, 1057-1061; 5 pages.
Düffels, et al.;Cationic Lipids for Gene Therapy, Part III[=],Synthesis of High-Mannose Type Neoglycolipids: Active Targeting of Liposomes to Macrophages in Gene Therapy; Research Article; Chem. Eur. J. 2000, vol. 6, No. 8; 1416-1430; 15 pages.
Themis, et al.;Enhanced In Vitro and In Vivo Gene Delivery Using Cationic Agent Complexed Retrovirus Vectors; Research Article; Gene Therapy vol. 5 (1988); 1180-1186; 7 pages.
Nakhla, et al.;Issues Associated with Large-Scale Production of Liposomal Formulations; web article, Drug Delivery Technologies; www.drugdeliverytech.com; Mar. 5, 2004; 10 pages.
Miller;Gene Therapy; Research Article; webpage excerpt from www.thebiotechclub.org/industry/emerging/gene—therapy.php; GSAS Harvard Biotechnology Club Mar. 3, 2004; 6 pages.
Alza's Stealth® Liposomal Technology: Current Therapies and Future Opportunities; webpage article: www.alza.com; Delivery Times, Issues and Opportunities, vol. 2, No. 1; Alza Corporation; 12 pages.
Bramwell, et al.;Liposome/DNA Complexes Coated with Biodegradable PLA Improve Immune Responses to Plasmid Encoding Hepatitis B Surface Antigen; Research Article; Immunology vol. 106 (2002) 412-418; 7 pages.
Frézard;Liposomes: From Biophysics to the Design of Peptide Vaccines; Braz J Med Biol Res, Feb. 1999, vol. 32(2) 181-189; 9 pages.
Kucerka, et al., Determination of bilayer thickness and lipid surface area in unilamellar dimyristoylphosphatidylcholine vesicles from small-angle neutron scattering curves: a comparison of evaluation methods, Eur Biophs J (2004) 33: pp. 328-334.
International Preliminary Report on Patentability and Written Opinion for International Application No. PCT/US08/050945, filed on Jan. 12, 2008, 6 pages.
International Preliminary Report on Patentability and Written Opinion for International Application No. PCT/US08/050946, filed on Jan. 12, 2008, 4 pages.
Christie Parker & Hale LLP
Del Sole Joseph S
Malekzadeh Seyed Masoud
LandOfFree
Method and apparatus for making uniformly sized particles does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for making uniformly sized particles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for making uniformly sized particles will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2646512