Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2002-04-03
2008-01-01
Lam, Ann Y (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
Reexamination Certificate
active
07314718
ABSTRACT:
The present invention provides a method of performing analyses and assays involving multiple interactions of reagent-containing fluid flows with liquid and solid target substances. The methods of the invention allow the simultaneous manipulation of different fluids on a small planar surface. The invention also provides a flow cell and method of use thereof for analyzing fluid-fluid and fluid-solid interactions in a substantially planar system. The flow cell contains at least one chamber and a plurality of inlets thereto allowing the introduction of a plurality of fluids in fluidic contact. The cell depth is the smallest dimension of the flow cell, and is of a magnitude, from about 50 to about 1000 microns such that any mixing of adjacent fluids in the chamber is substantially limited to mixing by passive diffusion. Interactions between reagents in fluids and target substances maintained in the fluid cell, or interactions between diffusion-mixed reagents in adjacent fluids, may be analyzed by standard analysis methods.
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http://www.erc.montana.edu/˜paul—s/biofilm—flow.htm; Flow Cells and Image Analysis; May 22, 2002.
Berg Jordan Mitchell
Dasgupta Purnendu Kumar
Surowiec Kazimierz
BioArray Solutions Ltd.
Lam Ann Y
Mirabel Eric P.
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