Method and apparatus for ion fragmentation in mass spectrometry

Details Method and apparatus for ion fragmentation in mass spectrometry Method and apparatus for ion fragmentation in mass spectrometry

2008-07-08

2008-07-08

Berman, Jack I. (Department: 2881)

Radiant energy

Ionic separation or analysis

With sample supply means

C250S283000, C250S285000, C250S293000

Reexamination Certificate

active

07397029

ABSTRACT:
An apparatus for mass analyzing molecules includes a mass spectrometer configured to select precursor ions having a mass to charge ratio range, a metastable species generator configured to generate a metastable species for introduction into the mass spectrometer, and a mass detector configured to detect a mass of the product ions. The apparatus also includes interaction region in the mass spectrometer where the precursor ions are converted into product ions via interaction of the precursor ions with the metastable species. The mass spectrometer includes at least one of a three-dimensional ion trap, a linear ion trap, or an ion guide. The interaction region is located inside the three-dimensional ion trap, the linear trap, or the ion guide; and at least one of the precursor ions or at least one of the product ions are excited by an alternating electric field or collisionally activated to produce additional product ions.

REFERENCES:
patent: 5420425 (1995-05-01), Bier et al.
patent: 5464975 (1995-11-01), Kirchner et al.
patent: 6124675 (2000-09-01), Bertrand et al.
patent: 6140638 (2000-10-01), Tanner et al.
patent: 6177668 (2001-01-01), Hager
patent: 6285027 (2001-09-01), Chernushevich et al.
patent: 6723983 (2004-04-01), Holle
patent: 2002/0145110 (2002-10-01), Holle
patent: 2005/0001161 (2005-01-01), Hiracka
patent: 2005/0272164 (2005-12-01), Zhu et al.
patent: 2006/0273254 (2006-12-01), Berkout et al.
patent: 2007/0114384 (2007-05-01), Berkout et al.
John N. Louris et al, Instrumentation, Applications, and Energy Deposition in Quadrupole Ion-Trap Tandem Mass Spectrometry, Anal. Chem. 1987, vol. 59, pp. 1677-1685.
Roman A. Zubarev et al., Electron Capture Dissociation of Multiply Charged Protein Cations. A Nonergodic Process, J. Am., Chem. Soc. 1998, vol. 120, pp. 3265-3266.
Cris L. Lewis et al., Time-Gated Pulsed Glow Discharge: Real-Time Chemical Speciation at the Elemental, Structural, and Molecular Level for Gas Chromatography Time-Of-Flight Mass Spectrometry, Anal. Chem., May 1, 2003, vol. 75, No. 9, pp. 1983-1996.
Stephen J. Valentine et al., A Database of 660 Peptide Ion Cross Sections: Use of Intrinsic Size Parameters for Bona Fide Predictions of Cross Sections, J. Am. Soc. Mass Spectrom 1999, vol 10, pp. 1188-1211.

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