Method and apparatus for intrapulmonary delivery of heparin

Details Method and apparatus for intrapulmonary delivery of heparin Method and apparatus for intrapulmonary delivery of heparin

1984-08-07

1987-07-14

Recla, Henry J.

Surgery

Respiratory method or device

Means for mixing treating agent with respiratory gas

604 58, A61M 1500

Patent

active

046795553

ABSTRACT:
An apparatus comprised of a canister having a valved opening thereon and containing, under pressure, heparin and a low boiling point propellant is disclosed. The valved opening can be activated to release a metered dose of aerosolized heparin to a patient or preferably to an inhalation device which improves efficiency with respect to the amount of heparin reaching the lungs of the patient.

REFERENCES:
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patent: 3404681 (1968-10-01), Fowler
patent: 3727806 (1973-04-01), Wilmot
patent: 3897779 (1975-08-01), Hanson
patent: 4052985 (1977-10-01), Coleman et al.
patent: 4484577 (1984-11-01), Sackner et al.
Jaques et al., Intrapulmonary Heparin . . . , The Lancet, Nov. 27, 1976, pp. 1157-1161.
Hellgren et al., Heparin Aerosol . . . , Thrombosis Research, vol. 21, pp. 493-502, 1981.
L. B. Jaques, Heparin: An Old Drug with a New Paradigm, Science, Nov. 1979, vol. 206, pp. 528-533.
Merck Index, Tenth Edition, Entry No. 4543.
U.S. Pharmacopeia National Formulary, 1980, vol. XX, p. 365.

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