Method and apparatus for inducing controlled mechanical...

Details Method and apparatus for inducing controlled mechanical... Method and apparatus for inducing controlled mechanical...

2011-03-15

2011-03-15

Beisner, William H (Department: 1775)

Chemistry: molecular biology and microbiology

Apparatus

Bioreactor

C435S284100, C435S366000, C073S829000, C073S858000, C073S831000, C073S836000

Reexamination Certificate

active

07906322

ABSTRACT:
A method and a device (10) for reorganizing the fibers of a matrix in a living tissue sheet (S) by inducing controlled mechanical constraints in the living tissue (S) sheet thus causing the fibers of the matrix to be aligned parallel to the strain orientation. The sheet (S) is held in a stretched state until the fibers set in place.

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Sadoshima, J-I et al: “Molecular Characterization of the Stretch-Induced Adaptation of Cultured Cardiac Cells An In-Vitro Model of Load-Induced Cardiac Hypertrophy” Journal of Biological Chemistry, vol. 267, No. 15, 1992 pp. 10551-10560.
“Tytron™ 250 Microforce Testing System” 2001, MTS Systems Corporation, US, Retrieved from Internet.

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