Radiant energy – Ionic separation or analysis – With sample supply means
Patent
1996-08-21
1998-11-17
Nguyen, Kiet T.
Radiant energy
Ionic separation or analysis
With sample supply means
250281, 250282, H01J 4910
Patent
active
058380027
ABSTRACT:
An electrospray ion production method and ion source designed to reduce overall gas load on the vacuum system and enhance the ion production and collection efficiencies. This ion source is for gas phase ion analysis of constituents dissolved in liquid solution comprising a needle (10) held at high electrical potential through which the solution flows into a first chamber (1) maintained at reduced pressure, forming a highly charged liquid cone-jet. The highly charged liquid jet is steered, in the first chamber, on-axis with an aperture into a second chamber (2) maintained at higher pressure than that of the first chamber. The second chamber is heated and pressurized to facilitate desolvation of the solution droplets originating from the breakup of the highly charged jet, resulting in the production of gas phase ions by the electrospray ionization process. The gas phase ions are then sampled and detected. Alternative reactions and/or inputs of energy via collision and/or radiation may occur in the second chamber to further facilitate ion production or fragmentation and may further enhance sample identification. This method and device may be useful in the implementation of liquid chromatography-mass spectrometry.
REFERENCES:
patent: 4160161 (1979-07-01), Horton
patent: 4999493 (1991-03-01), Allen et al.
patent: 5015845 (1991-05-01), Allen et al.
patent: 5115131 (1992-05-01), Jorgenson et al.
patent: 5393975 (1995-02-01), Hail et al.
Dohmier, D.M.; Open tubular liquid chromotography: Studies in column efficiency and detection, Chap 4, pp. 92-172 (Thesis, 1992). Has no month.
Cook, K.D.; Electrohydrodynamic mass spectrometry, Mass Spec. Rev. 1986 5, pp. 467-519. Has no month.
Dulcks and Rollgen; Ion source for electrohydrodynamic mass spectrometry, J. Mass Spectom., 1995, 30, pp. 324-332. Has no month.
Mahoney, Perel, Lee and Legesse; A theoretical and experimental basis for producing very high biomolecular ions by EHD emission, IEEE, Oct. 1987, pp. 1-6.
Lee, Legesse, Mahoney and Perel; An EHD source for the mass spectral analysis of peptides, ASMS Conference, Jun. 1988.
Lee, Legesse, Mahoney, Perel; Electrohydrodynamic emission mass spectra of peptides, ASMS Conference, May 1989, pp. 1196-1197.
Mahoney et al.; Electrhydrodynamic ion source design for mass spectrometry: Ionization, ion optics and desolvation, ASMS Confer. pp. 548-549 Jun. 1990.
Grace and Marijnissen; A review of liquid atomization by electrical means, J. Aerosol Sci. 1994, 25, pp. 1005-1019.
Luttgens, Dulcks, Rollgen; Field Induced disintegration of glycerol solutions under vacuum and atmospheric . . . , Surf. Sci. 1992, 266, pp. 197-203.
Chem-Space Associates, Inc
Nguyen Kiet T.
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