Chemistry: analytical and immunological testing – Involving an insoluble carrier for immobilizing immunochemicals – Carrier is inorganic
Patent
1996-12-30
1998-07-07
Spiegel, Carol A.
Chemistry: analytical and immunological testing
Involving an insoluble carrier for immobilizing immunochemicals
Carrier is inorganic
435 6, 435 71, 435 74, 435 792, 435 793, 435 794, 435 795, 435962, 436518, 436524, 436528, 436531, 436807, G01N 33552
Patent
active
057767858
ABSTRACT:
A method and apparatus for immunoassays utilizes an improved collection technique of fluorescence induced emissions at the solid phase/liquid phase interface from surface plasmon resonance sensing devices. In a preferred embodiment, a solid phase substrate is coated with a thin film of a conducting material on which a first specific binding partner is directly or indirectly immobilized. The coated solid phase substrate is incubated with a liquid component comprised of a biological sample containing a specific ligand or analyte and a fluorescent labeled second specific binding partner in the case of immunometric assays, or a fluorescent labeled ligand or analog thereof in the case of competitive assays. The improvements in the method of light collection for the induced emission of surface plasmon resonance based sensing devices which involve
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Lin Jinn-nan
Wilson Christopher J.
Diagnostic Products Corporation
Mueth Joseph E.
Spiegel Carol A.
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