Method and apparatus for high pressure liquid chromatography

Details Method and apparatus for high pressure liquid chromatography Method and apparatus for high pressure liquid chromatography

2005-05-17

2005-05-17

Therkorn, Ernest G. (Department: 1723)

Liquid purification or separation

Processes

Chromatography

C210S101000, C210S137000, C210S143000, C210S198200

Reexamination Certificate

active

06893569

ABSTRACT:
This modified HPLC instrument has the HPLC pump force only solvent through the serial flow line including a sampler, column, and detector; while buffer is discharged into the solvent from a syringe pump via a tee connection in the flow line downstream from the HPLC pump. A stepper motor drives the syringe pump at a discharge rate to yield an intended buffer/solvent dilution ratio compared to the steady HPLC pump flow rate. A pressure transducer detects variances of the flow line pressures, and servo controls the stepper motor for increasing the flow rate upon increased pressures and decreasing the flow rate upon decreased pressures, to hold the dilution ratio constant.

REFERENCES:
patent: 3373872 (1968-03-01), Jiri
patent: 4116046 (1978-09-01), Stein
patent: 4840730 (1989-06-01), Saxena
patent: 5645717 (1997-07-01), Hjerten et al.
patent: 5730867 (1998-03-01), Drew et al.
patent: 5935522 (1999-08-01), Swerdlow et al.
patent: 6344172 (2002-02-01), Afeyan et al.

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