Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or...
Reexamination Certificate
2007-02-20
2007-02-20
Ketter, James (Department: 1636)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
C435S173400, C435S287100
Reexamination Certificate
active
10306849
ABSTRACT:
High frequency interfacing to biochemical membranes, such as supported bilayers and cell membranes, is carried out by supporting a biochemical membrane on a support surface while allowing access to the surface of the membrane through an opening in the support. A sharp tipped probe is positioned adjacent to the exposed surface of the membrane. The probe may have an inner core tip and a coaxial shield around the core tip that is electrically insulated therefrom. Radio frequency power is supplied to the probe to apply a localized radio frequency field to the membrane adjacent to the probe. Transport and binding events at the membrane are detected by changes in the field transmitted through the membrane and received by a receiving probe, or reflected from the membrane and received by the transmitting probe, and coupled therefrom to a detector for detection.
REFERENCES:
patent: 5581349 (1996-12-01), Halaka
patent: 5846708 (1998-12-01), Hollis et al.
patent: 5858666 (1999-01-01), Weiss
patent: 5936237 (1999-08-01), van der Weide
patent: 6246898 (2001-06-01), Vesely et al.
patent: 6287776 (2001-09-01), Hefti
patent: 6287874 (2001-09-01), Hefti
patent: 2003/0034453 (2003-02-01), Ookubo et al.
Maria A. Stuchly, et al., “Coaxial Line Reflection Methods for Measuring Dielectric Properties of Biological Substances at Radio and Microwave Frequencies—A Review,” IEEE Transactions on Instrumentation and Measurement, vol. IM-29, No. 3, Sep. 1980, pp. 176-183.
D.A. Haydon, et al., “The Admittance of Squid Giant Axon at Radio Frequencies and its Relation to Membrane Structure,” J. Physiol., vol. 360, 1985, pp. 275-291.
A. Ashkin, et al., “Observation of a Single-Beam Gradient Force Optical Trap for Dielectric Particles,” Optics Letters, vol. 11, No. 5, May 1986, pp. 288-290.
Atticus H. Hainsworth, et al., “Effects of Double-Layer Polarization on Ion Transport,” Biophys. J., vol. 51, Jan. 1987, pp. 27-36.
A.S. Pasynkov, “Polarizability of Bilayer Membranes on Phase Separation. Quasi-One-Dimensional Model,” Biophysics, vol. 32, No. 1, 1987, pp. 54-59.
Karunanayake P.A.P. Esselle, et al., “Capacitive Sensors for In-Vivo Measurements of the Dielectric Properties of Biological Materials,” IEEE Transactions on Instrumentation and Measurement, vol. 37, No. 1, Mar. 1988, pp. 101-105.
Thor Osborn, et al., “An Approach to the Stabilization of Lipid Bilayers Incorporating Ion Channels for Biosensing Applications,” IEEE Engineering in Medicine & Biology Society 11th Annual International Conference, 1989, pp. 1375-1376.
Satoru Mashimo, et al., “Dielectric Study on Dynamics and Structure of Water Bound to DNA Using a Frequency Range 107-1010 Hz,” J. Phys. Chem, vol. 93, 1989, pp. 4963-4967.
John Sandblom, et al., “The Effect of Microwave Radiation on the Stability and Formation of Gramicidin-A Channels in Lipid Bilayers Membranes,” Bioelectromagnetics, vol. 12, 1991, pp. 9-20.
Lars Malmqvist, et al., “Trapped Particle Optical Microscopy,” Optics Communications, vol. 94, 1992, pp. 19-24.
Yu D. Feldman, et al., “Time Domain Dielectric Spectroscopy. A New Effective Tool for Physical Chemistry Investigation,” Colloid & Polymer Science, vol. 270, 1992, pp. 768-780.
G. Fuhr, et al., “Radio-Frequency Microtools for Particle and Live Cell Manipulation,” Naturwissenschaften, vol. 81, 1994, pp. 528-535.
James Baker-Jarvis, et al., “Analysis of an Open-Ended Coaxial Probe with Lift-Off for Nondestructive Testing,” IEEE Transactions on Instrumentation and Measurement, vol. 43, No. 5, Oct. 1994, pp. 711-718.
Cy Tamanaha, et al., “An Inorganic Filter to Support Biomembrane-Mimetic Structures,” 1995 IEEE-EMBC and CMBEC, Theme 7: Instrumentation, 1995, pp. 1559-1569.
S.I. Alekseev, et al., “Millimeter Microwave Effect on Ion Transport Across Lipid Bilayer Membranes,” Bioelectromagnetics, vol. 16, 1995, pp. 124-131.
Vitaliy I. Geletyuk, et al., “Dual Effects of Microwaves on Single Ca2+-Activated K+ Channels in Cultured Kidney Cells Vero,” FEBS Letters, vol. 359, 1995, pp. 85-88.
Geoff Smith, et al., “Dielectric Relaxation Spectroscopy and Some Applications in the Parmaceutical Sciences,” Pharmaceutical Sciences, vol. 84, No. 9, Sep. 1995, pp. 1029-1043.
Andreas Janshoff, et al., “Applications of Impedance Spectrocscopy in Biochemistry and Biophysics,” Acta Biochimica Polonica, vol. 43, No. 2, 1996, pp. 339-348.
D.W. van der Weide, et al., “The Nanoscilloscope: Combined Topography and AC Field Probing with a Micromachined Tip,” J. Vac. Sci. Technol. B., vol. 14, No. 6, Nov./Dec., 1996, pp. 4144-4147.
D.W. van der Weide, “Localized Picosecond Resolution with a Near-Field Microwave/Scanning-Force Microscope,” Applied Physics Letters, vol. 70, No. 6, Feb. 10, 1997, pp. 677-6797.
Lukas Novotny, et al., “Theory of Nanometric Optical Tweezers,” Physical Review Letters, vol. 79, No. 4, Jul. 28, 1997, pp. 645-648.
Juris Galvanovskis, et al., “Amplification of Electromagnetic Signals by Ion Channels,” Biophysical Journal, vol. 73, Dec. 1997, pp. 3056-3065.
Charles L. Asbury, et al., “Trapping of DNA in Nonuniform Oscillating Electric Fields,” Biophysical Journal vol. 74, Feb. 1998, pp. 1024-1030.
D.A. Simson, et al., “Mircopipet-Basd Pico Force Transducer: In Depth Analysis and Experimental Verification,” Biophysical Journal, vol. 74, Apr. 1998, pp. 2080-2088.
Michael P. Hughes, et al., “Manipulation of Herpex Simplex Virus Type I by Dielectrophoresis,” Biochimica et Biophysica Acta, vol. 1425, 1998, pp. 119-126.
Web pages entitled “CMBE Interdisciplinary Research Expertise in the Technology of Functional Molecular Layers,” printed Jul. 24, 1999.
Web pages entitled “The ICS Biosensor-Functional Overview-AMBRInstitute,” pp. 1-8, printed Jul. 30, 1999.
Thierry Stora, et al., “Ion-Channel Gating in Transmembrane Receptor Proteins: Functional Activity in Tethered Lipid Membranes,” Angew. Chem. Int. Ed., vol. 38, No. 3, 1999, pp. 389-392.
Christian Schmidt, et al., “A Chip-Based Biosensor for the Functional Analysis of Single ion Channels,” Angew. Chem. Int. Ed., vol. 39, No. 17, 2000, pp. 3137-3140.
J.E.M. McGeoch, et al., “Biological-to-Electronic Interface with Pores of ATP Synthase Subunit C in Silicon Nitride Barrier, ” Med. Biol. Eng. Comput., vol. 38, 200, pp. 113-119.
Wolfgang Meier, et al., “Reconstitution of Channel Proteins in (Polymerized) ABA Triblock Copolymer Membranes,”Angew. Chem. Int. Ed., vol. 39, No. 24, 2000, pp. 4599-4602.
G.I. Ovchinnikova, “The Role of Charge Transport in the Reception of Electromagnetic Radiation,”Critical Reviews in Biomedical Engineering, 2000, pp. 77-82.
Hagan Bayley, et al., “Resistive-Pulse Sensing—From Microbes to Molecules,” Chem. Rev., vol. 100, 2000. pp. 2575-2594.
Frida Ryttsen, et al., “Characterization of Single-Cell Electroporation by Using Patch-Clamp and Fluorescence Microscopy,” Biophyscial Journal, vol. 79, Oct., 2000, pp. 1993-2001.
Shigeru Amemiya, et al., “Scanning Electrochemical Microscopy. 40. Voltammmetric Ion-Selective Micropipet Electrodes for Probing Ion Transfer at Bilayer Lipid Membranes,” Analytical Chemistry, vol. 72, No. 20.
Samual Terrettaz, et al., “Immunosensing by a Synthetic Ligand-Gated Ion Channel,” Angew. Chem. Int. Ed, vol. 40, No. 9, 2001, pp. 1740-1743.
Erwin Neher, “Molecular Biology Meets Microelectronics,” Nature Biotechnology, vol. 19, Feb. 2001, p. 114.
Israel Garcia-Ruiz, et al., “Measuring Complex Permittivity of Materials for Frequencies Under 18 GHz,” Applied Microwave & Wireless, Jun. 2001, pp. 56-66.
A. Maureen Rouhi, “From Membranes to Nanotubules,” Chemical & Engineering Ne
Ketter James
Wisconsin Alumni Research Foundation
LandOfFree
Method and apparatus for high frequency interfacing to... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for high frequency interfacing to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for high frequency interfacing to... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3869932