Method and apparatus for estimating oxygen saturation of blood u

Details Method and apparatus for estimating oxygen saturation of blood u Method and apparatus for estimating oxygen saturation of blood u

1991-08-08

1993-08-10

Jaworski, Francis

Surgery

Truss

Pad

1286533, A61B 5055

Patent

active

052339912

ABSTRACT:
The oxygen saturation of blood is determined by obtaining spin-spin relaxation time (T2.sub.b) of the fluid using magnetic resonance imaging techniques. A simplified model relates oxygen saturation of blood to measured spin-spin relaxation time. A pulse sequence is given for in vivo estimation of T2.sub.b including a plurality of 180.degree. refocusing RF signals which are equally spaced in time. The last refocusing pulse is slice selective. Fat signal is suppressed by initially using a short inversion recovery sequence followed by a frequency selective 90.degree. pulse that excites only water protons.

REFERENCES:
patent: 4775522 (1988-10-01), Clark, Jr.
patent: 4984574 (1991-01-01), Goldberg et al.
John M. Gomori, et al., "NMR Relaxation Times of Blood: Dependence on Field Strength, Oxidation State, and Cell Integrity," Journal of Computer Assisted Tomography, 11(4): 684-690, Jul./Aug. .COPYRGT.1987 Raven Press, N.Y.
K. R. Thulborn, et al., "Proton Imaging for in Vivo Blood Flow and Oxygen Consumption Measurements," Journal of Magnetic Resonance, 45, 188-191 (1981). Copyright .COPYRGT.1981 by Academic Press, Inc.
Keith R. Thulborn, et al., "Oxygenation Dependence of the Transverse Relaxation Time of Water Protons in Whole Blood at High Field," Biochimica et Biophysica Acta, 714 (1982) 265-270 .COPYRGT.Elsevier Biomedical Press.
G. A. Wright, et al., "Estimating Oxygen Saturation of Blood in vivo with MRI at 1.5T," Society of Magnetic Resonance in Medicine, (Works in Progress) Ninth Annual Scientific Meeting and Exhibition Aug. 18-24, 1990 New York, N.Y. USA.
Graham A. Wright, et al., "Estimating Oxygen Saturation of Blood in Vivo with MR Imaging at 1.5T.sup.1," JMRI, vol. 1 No. 3 275-284, May/Jun. 1991 .COPYRGT.SMRI, 1991.

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