Method and apparatus for estimating molecular mass from electros

Radiant energy – Ionic separation or analysis – Methods

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

364498, H01J 4900

Patent

active

053528913

ABSTRACT:
The production of mass spectra of chemical compounds of high molecular weights having a multiplicity of peaks is improved by generating an enhanced mass spectrum from the observed mass-to-charge spectrum. The intensity at each point within the enhanced spectrum is based upon a plurality of successive discrete peaks within the mass-to-charge spectrum. The intensities of the sequence of mass-to-charge peaks are combined to form a normalized product which is the new enhanced intensity at an assumed molecular weight. The intensities of the mass-to-charge spectrum at each integral fraction of the assumed molecular weight are included in the product. Only those intensities above a certain predetermined threshold, however, are included to avoid transfer of noise into the enhanced spectrum. Signal-to-noise ratio can in some applications be improved by including in the product all portions within the discrete peaks in the mass-to-charge spectrum which are contained within a window around each of the discrete peaks.

REFERENCES:
patent: 5072115 (1991-12-01), Zhou
patent: 5130538 (1992-07-01), Fenn et al.
"Interpreting Mass Spectra of Multiply Charged Ions," Mann et al., Anal. Chem. 1989, 61, 1702-1708.
"Electrospray Ionization Mass Spectrometry: Deconvolution . . . ," Reinhold et al., J Am Soc Mass Spectrom 1992, 3, 207-215.
"Tandem Mass Spectrometry of Very Large Molecules: Serum Albumin . . . ," Loo et al., Anal. Chem. 1991, 63, 2488-2499.
"New Developments in Biochemical Mass Spectrometry: Electrospray Ionization," Perspective: Analytical Bitechnology, Anal Chem. 1990, 62, 882-899.
"Electrospray Mass Sepctrometry of Poly(ethylene glycols) with Molecular . . . ," Nohmi et al., J. Am. Chem. Soc. 1992, 114, 3241-3246.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method and apparatus for estimating molecular mass from electros does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and apparatus for estimating molecular mass from electros, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for estimating molecular mass from electros will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-583168

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.