Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...
Reexamination Certificate
2007-01-09
2007-01-09
Marmor, II, Charles A (Department: 3735)
Surgery
Diagnostic testing
Measuring or detecting nonradioactive constituent of body...
C600S309000, C600S365000, C204S403010, C204S403140
Reexamination Certificate
active
10335574
ABSTRACT:
A method and apparatus for enhancing the integrity of an implantable sensor. Voids formed between an outer tubing and a sensor substrate or spacing element may be back-filled with a curable, implantable material, minimizing the extent to which unwanted fluids diffuse within the sensor. An enzyme or protein matrix pellet below the sensor window may be pre-treated with a reducing agent to enhance its bond stability, and to reduce undesired swelling that may cause the sensor window to detach or leak. The bonding between the enzyme pellet and a hydrogel layer may be reinforced by application of an intervening bonding layer of a protein material, such as human serum albumin (HSA). The size of the window may be minimized by minimizing the size of an underlying electrode, providing reduced flux and lengthening sensor. A coating may be deposited on the surface of the sensor leads, providing stiffening and lubrication.
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PCT International Search Report as issued in International Application No. PCT/US03/28854, Mailing date Aug. 9, 2004.
Gottlieb Rebecca
Miller Michael
Reghabi Bahar
Shah Rajiv
Zhang Yanan
Foley & Lardner LLP
Mallari Patricia
Marmor II Charles A
Medtronic Minimed Inc.
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