Chemistry: molecular biology and microbiology – Condition responsive control process
Reexamination Certificate
2008-01-01
2008-01-01
Moran, Marjorie A. (Department: 1631)
Chemistry: molecular biology and microbiology
Condition responsive control process
C435S006120, C422S068100, C422S050000, C530S333000, C530S334000, C530S335000, C536S025300
Reexamination Certificate
active
07314708
ABSTRACT:
A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antigen reaction, diagnostics, and biopolymer synthesis. The device can be fabricated using both microlithographic and micro-machining techniques. The device can electronically control the transport and attachment of specific binding entities to specific micro-locations. The specific binding entities include molecular biological molecules such as nucleic acids and polypeptides. The device can subsequently control the transport and reaction of analytes or reactants at the addressed specific micro-locations. The device is able to concentrate analytes and reactants, remove non-specifically bound molecules, provide stringency control for DNA hybridization reactions, and improve the detection of analytes. The device can be electronically replicated.
REFERENCES:
patent: 3950738 (1976-04-01), Hayashi et al.
patent: 3995190 (1976-11-01), Salgo
patent: 4225410 (1980-09-01), Pace
patent: 4283773 (1981-08-01), Daughton et al.
patent: 4537861 (1985-08-01), Elings et al.
patent: 4563419 (1986-01-01), Ranki et al.
patent: 4580895 (1986-04-01), Patel
patent: 4584075 (1986-04-01), Goldstein et al.
patent: 4594135 (1986-06-01), Goldstein
patent: 4661451 (1987-04-01), Hansen
patent: 4731325 (1988-03-01), Palva et al.
patent: 4751177 (1988-06-01), Stabinsky
patent: 4787963 (1988-11-01), MacConnell
patent: 4807161 (1989-02-01), Comfort et al.
patent: 4816418 (1989-03-01), Mack et al.
patent: 4822566 (1989-04-01), Newman
patent: 4828979 (1989-05-01), Klevan et al.
patent: 4908112 (1990-03-01), Pace
patent: 4936963 (1990-06-01), Mandecki et al.
patent: 5063081 (1991-11-01), Cozzette et al.
patent: 5064519 (1991-11-01), Tice, Jr. et al.
patent: 5074977 (1991-12-01), Cheung et al.
patent: 5075077 (1991-12-01), Durley, III et al.
patent: 5096669 (1992-03-01), Lauks et al.
patent: 5096807 (1992-03-01), Leaback
patent: 5110434 (1992-05-01), Zhu et al.
patent: 5114674 (1992-05-01), Stanbro et al.
patent: 5125748 (1992-06-01), Bjornson et al.
patent: 5126022 (1992-06-01), Soane et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5164319 (1992-11-01), Hafeman et al.
patent: 5166063 (1992-11-01), Johnson
patent: 5200051 (1993-04-01), Cozzette et al.
patent: 5202231 (1993-04-01), Drmanac et al.
patent: 5219726 (1993-06-01), Evans
patent: 5227265 (1993-07-01), DeBoer et al.
patent: 5234566 (1993-08-01), Osman et al.
patent: 5242797 (1993-09-01), Hirschfeld
patent: 5304487 (1994-04-01), Wilding et al.
patent: 5312527 (1994-05-01), Mikkelsen et al.
patent: 5433819 (1995-07-01), McMeen
patent: 5434049 (1995-07-01), Okano et al.
patent: 5436129 (1995-07-01), Stapleton
patent: 5445525 (1995-08-01), Broadbent et al.
patent: 5445934 (1995-08-01), Fodor et al.
patent: 5464517 (1995-11-01), Hjerten et al.
patent: 5468646 (1995-11-01), Mattingly
patent: 5516698 (1996-05-01), Begg et al.
patent: 5527670 (1996-06-01), Stanley
patent: 5593838 (1997-01-01), Zanzucchi et al.
patent: 5605662 (1997-02-01), Heller et al.
patent: 5632957 (1997-05-01), Heller et al.
patent: 5653939 (1997-08-01), Hollis et al.
patent: 5660701 (1997-08-01), Grushka et al.
patent: 5667667 (1997-09-01), Southern
patent: 5681751 (1997-10-01), Begg et al.
patent: 5726026 (1998-03-01), Wilding et al.
patent: 5744305 (1998-04-01), Fodor et al.
patent: 5750015 (1998-05-01), Soane et al.
patent: 5846708 (1998-12-01), Hollis et al.
patent: 5849486 (1998-12-01), Heller et al.
patent: 5853668 (1998-12-01), Begg et al.
patent: 5929208 (1999-07-01), Heller et al.
patent: 5965452 (1999-10-01), Kovacs
patent: 6013166 (2000-01-01), Heller
patent: 6017696 (2000-01-01), Heller et al.
patent: 6048690 (2000-04-01), Heller et al.
patent: 6051380 (2000-04-01), Sosnowski et al.
patent: 6054270 (2000-04-01), Southern
patent: 6093302 (2000-07-01), Montgomery
patent: 6238624 (2001-05-01), Heller et al.
patent: 6444111 (2002-09-01), Montgomery
patent: 0228075 (1987-07-01), None
patent: 2156074 (1985-10-01), None
patent: 2247889 (1992-03-01), None
patent: WO86/03782 (1986-07-01), None
patent: WO88/08528 (1988-11-01), None
patent: WO89/01159 (1989-02-01), None
patent: WO89/10977 (1989-11-01), None
patent: WO90/01564 (1990-02-01), None
patent: WO92/04470 (1992-03-01), None
patent: WO93/22678 (1993-11-01), None
patent: WO95/07363 (1995-03-01), None
patent: WO96/01836 (1996-01-01), None
patent: WO98/01758 (1998-01-01), None
patent: WO98/51819 (1998-11-01), None
Abrams et al. “Comprehensive Detection of Single Base Changes In Human Genomic DNA Using Denaturing Gradient Gel Electrophoresis & a GC Clamp”.Genomics, 7, 1990, 463-475.
Anand and Southern “Pulsed Field Gel Electrophoresis,”Gel Electrophoresis of Nucleic Acids—A Practical Approach, 2d. Ed., D. Rickwood and B.D. Hames (New York:IRL Press 1990), pp. 101-123.
Anderson and Young, “Quantitative Filter Hybridization,”Nucleic Acid Hybridization—A Practical Approach, Eds. B.D. Hames and S.J. Higgins (Washington, D.C. :IRL Press 1985) pp. 73-111.
Bains, “Setting a Sequence to Sequence a Sequence,”Bio/Technology, 10:757-758 (1992).
Barinaga, “Will ‘DNA Chip’ Speed Genome Initiative?”,Science, 253:1489 (1991).
Beattie et al., “Genosensor Technology,”The 1992 San Diego Conference: Genetic Recognition, pp. 1-5 (Nov. 1992).
Beltz et al., “Isolation of Multigene Families and Determination of Homologies by Filter Hybridization Methods,”Methods in Enzymology, 100:266-285 (1983).
Brown et al. “Electrochemically Induced Adsorption of Radio-Labelled DNA on Gold and HOPG Substrates for STM Investigations”.Ultramicroscopy, 38, 1991, 253-264.
Conner et al., “Detection of Sickle Cell □3-Globin Allele by Hybridization With Synthetic Oligonucleotides,”Proc. Natl. Acad. Sci. USA, 80:278-282 (1983).
Drmanac et al., “Sequencing of Megabase Plus DNA by Hybridization: Theory of the Method,”Genomics, 4:114-128 (1989).
Drmanac et al., “DNA Sequence Determination by Hybridization: A Strategy for Efficient Large-Scale Sequencing,”Science, 260: 1649-1652 (1993).
Eggers et al. “Biochip Technology Development”, BioChip Technology Development, Lincoln Laboratory Technical Report 901, Nov. 9, 1990, 63 pages.
Fiaccabrino et al., “Array of Individually Addressable Microelectrodes”,Sensors and Actuators B, 18-19 (1994) 675-677.
Fodor et al., “Multiplexed Biochemical Assays With Biological Chips,”Nature, 364:555-556 (1993).
Fodor et al., “Light-Directed, Spatially Addressable Parallel Chemical Synthesis,”Science, 251:767-773 (1992).
Horejsi, “Some Theoretical Aspects of Affinity Electrophoresis,”Journal of Chromatography, 178:1-13 (1979).
Horejsi et al., Determination of Dissociation Constants of Lectin Sugar Complexes by Means of Affinity Electrophoresis,Biochimica at Biophysica Acta, 499:200-300 (1977).
Kakerow et al., “A Monolithic Sensor Array of Individually Addressable Microelectrodes”,Sensors and Actuators A, 43 (1994) 296-301.
Mathews, Kricka. “Analytical Strategies For The Use Of DNA Probes”.Analytical Biochemistry, 169, 1988, 1-25.
Palecek. “New Trends in Electrochemical Analysis of Nucleic Acids”.Bioelectrochemistry and Bioenergetics, 20, 1988, 179-194.
Ranki et al., “Sandwich Hybridization as a Convenient Method for the Detection of Nucleic Acids in Crude Samples,”Gene, 21:77-85 (1983).
Saiki, “Amplification of Genomic DNA,”PCR Protocols: A Guide to Methods and Applications, (Academic Press, Inc. 1990), pp. 13-20.
Southern et al., “Analyzing and Comparing Nucleic Acid Sequences by Hybridization to Arrays of Oligonucleotides Evaluation Using Experimental Models,”Genomics, 13:1008-1017 (1992).
Strezoska et al., “DNA Sequencing by Hybridizati
Heller Michael J.
Tu Eugene
Moran Marjorie A.
Nanogen Inc.
O'Melveny & Myers LLP
LandOfFree
Method and apparatus for electronic synthesis of molecular... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for electronic synthesis of molecular..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for electronic synthesis of molecular... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2777429