Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...
Reexamination Certificate
2007-07-24
2007-07-24
Winakur, Eric (Department: 3768)
Surgery
Diagnostic testing
Measuring or detecting nonradioactive constituent of body...
C600S326000, C600S328000
Reexamination Certificate
active
11103963
ABSTRACT:
A device and method utilizes a broadband diffuse optical spectroscopy (DOS) system to dynamically calculate the concentrations of multiple chromophores in vivo using a non-invasive probe. The device and method permit dynamic monitoring of multiple in vivo tissue chromophores non-invasively with sensitivities necessary for effective therapeutic monitoring. The device includes a probe containing first and second source optical fibers as well as first and second detector optical fibers. The probe is placed adjacent to a sample of interest and detects reflected light which is passed to a proximally located detector and spectrometer. The concentrations of multiple chromophores are determined in real time. In a preferred embodiment, the multiple tissue chromophores include at least two of methemoglobin (MetHb), deoxyhemoglobin (Hb-R), oxyhemoglobin (Hb-O2), water (H2O), and methylene blue (MB). The device and method can be used quantify and monitor methemoglobin formation in subjects suffering from methemoglobinemia.
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Brenner Matthew
Cerussi Albert E.
Lee Jangwoen
Tromberg Bruce J.
Berhanu Etsub
The Regents of the University of California
Vista IP Law Group LLP
Winakur Eric
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