Method and apparatus for dosing single and multi-agent therapy

Details Method and apparatus for dosing single and multi-agent therapy Method and apparatus for dosing single and multi-agent therapy

2005-04-26

2005-04-26

Lacyk, John P. (Department: 3736)

Surgery

Miscellaneous

Methods

C600S300000

Reexamination Certificate

active

06883521

ABSTRACT:
An improved method and apparatus using a newly defined nonlinear technology that more accurately describes the biological process of dose titration to calculate next agent dose(s) in single and multi-agent therapy. The overall proportion of each agent is determined by the amount of agent as it relates to the dosing range. The overall proportion as well as the intrinsic potency of the agent is used to determine the total proportional effect that each agent has on the surrogate marker. This parameter is then inserted into the four-parameter equation for calculating dose by adjusting the proportional change in marker that is attributed to the activity of the agent.

REFERENCES:
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patent: 5542436 (1996-08-01), McMichael
patent: 5694950 (1997-12-01), McMichael
patent: 6267116 (2001-07-01), McMichael
patent: 6575169 (2003-06-01), McMichael
patent: 6578582 (2003-06-01), McMichael

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