Method and apparatus for disrupting cells in a fluid...

Details Method and apparatus for disrupting cells in a fluid... Method and apparatus for disrupting cells in a fluid...

2007-07-10

2007-07-10

Banks, Derris H. (Department: 3725)

Solid material comminution or disintegration

Processes

With cell rupturing or liberation of contained liquids

C241S038000, C417S454000

Reexamination Certificate

active

10937338

ABSTRACT:
Method for disruptingS. Cerevisiaeyeast cells in an aqueous solution, by means of a continuous process under high pressure (up to 4000 bar), using a homogenizer.The suspension to be processed passes through a homogenizing valve with a “sharp edge” or “knife edge” passage head in order to achieve a 100% cell disruption rate with a single passage, at a dynamic pressure equal to or above 2000 bar.The “sharp edge” or “knife edge” profile of the passage head (4) is characterized by an inside diameter (9) of 10.9-14 mm and an outside diameter (10) of 11.9 mm-15 mm, and operates at a flow rate of 100-500 liters/hour and a dynamic pressure of more than 2000 bar.

REFERENCES:
patent: 5411380 (1995-05-01), Bristol et al.
patent: 5972642 (1999-10-01), Flenø et al.
patent: 6110469 (2000-08-01), Singh et al.
patent: 6951746 (2005-10-01), Tanimoto et al.
patent: 6987173 (2006-01-01), Lee et al.

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