Surgery – Truss – Pad
Patent
1991-08-09
1993-09-28
Cohen, Lee S.
Surgery
Truss
Pad
36441313, A61B 5055
Patent
active
052479340
ABSTRACT:
Methods are provided for detecting and diagnosing osteoporosis using high-resolution NMR imaging of trabecular bone. One such method comprises the steps of obtaining high-resolution NMR imaging data indicative of the trabecular microstructure of a mass of bone, analyzing the imaging data to determine the density of the trabeculae of the bone, comparing the density thus obtained with reference trabecular density data, and determining on the basis of the comparison whether the subject is osteoporotic or normal. To determine trabecular density, bone volume can be computed as the area fraction of those pixels that by virtue of their characteristic pixel intensity can be assigned to bone. Trabecular thickness can be computed from the relative bone area in a region of interest divided by half the perimeter length, the perimeter length being the circumference of all bone islands observed in the region of interest. Trabecular density can be expressed as the mean number of intercepts of parallel search lines perpendicular to the orientation of the trabeculae or as the ratio of mean trabecular thickness divided by the bone area within the region of interest.
REFERENCES:
patent: 4635643 (1987-01-01), Brown
patent: 4721112 (1988-01-01), Hirano et al.
patent: 4829549 (1989-05-01), Vogel et al.
patent: 4850372 (1989-07-01), Ko et al.
patent: 4903203 (1990-02-01), Yamashita et al.
patent: 4922915 (1990-05-01), Arnold et al.
patent: 4976267 (1990-12-01), Jeffcott et al.
patent: 5038786 (1991-08-01), Kojima
patent: 5081992 (1992-01-01), Levin et al.
Parfitt, "Age-related Structural Changes in Trabecular and Cortical Bone: Cellular Mechanisms and Biomechanical Consequences," Calcif Tissue Int 36: 123-5128, 1984.
Kleerekoper et al., "The Role of Three-Dimensional Trabecular Microstructure in the Pathogenesis of Vertebral Compression Fractures," Calcif Tissue Int 37:594-597, 1985.
Weinstein et al., "Decreased Trabecular Width and Increased Trabecular Spacing Contribute to Bone Loss with Aging," Bone 8:137-142, 1987.
Whitehouse, "The Quantitative Morphology of Anisotropic Trabecular Bone," J Microsc 101:153-168, 1974.
Gundersen, et al., "Some New, Simple and Efficient Stereological Methods and Their Use in Pathological Research and Diagnosis," APMIS 96:379-394, 1988.
Schenck et al., "High Resolution Magnetic Resonance Imaging Using Surface Coils," Magnetic Resonance Annual (1986).
Bittoun et al., "In Vivo High-Resolution MR Imaging of the Skin in a Whole-Body System at 1.5T," Radiol 176:457-460, 1990.
Parfitt et al., "Relationships Between Surface, Volume, and Thickness of Iliac Trabecular Bone in Aging and in Osteoporosis," J. Clin. Invest. 72:1396-1409, 1983.
Williams et al., "Properties and an Anisotropic Model of Cancellous Bone from the Proximal Tibial Epiphysis," J Biomechanical Engineering 104:50-56, 1982.
Raux et al., "Trabecular Architecture of the Human Patella," J Biomechanics 8:1-7, 1975.
Wehrli et al., "MR Microscopy of Trabecular Microstructure In Vitro and In Vivo," J. Magn Res Imaging 1:221-222, 1991.
Kugelmass Steven D.
Wehrli Felix W.
Cohen Lee S.
Pfaffle K. M.
Trustees of the University of Pennsylvania
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