Method and apparatus for diagnosing osteoporosis

Details Method and apparatus for diagnosing osteoporosis Method and apparatus for diagnosing osteoporosis

1991-05-21

1993-12-14

Tokar, Michael J.

Electricity: measuring and testing

Particle precession resonance

Using a nuclear resonance spectrometer system

324300, 1286532, G01R 3320

Patent

active

052706516

ABSTRACT:
A method for noninvasively detecting osteoporosis in human subjects by means of NMR imaging is described. In the preferred embodiment, a series of images are acquired whereby the echo time TE is incremented until a predefined number of images, each differing in echo time, has been acquired. The images are then displayed, a region of interest (ROI) is selected and mean signal amplitudes are computed (block 46). The mean signal amplitude values are then used as inputs for the curve fitting procedure that computes T2* (block 48). The final step of the process compares the computed value of T2* with a normal baseline (block 50), which permits the subject to be classified as either normal or osteoporotic (block 52).

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F. W. Wehrli, J. C. Ford, D. A. Gusnard et al., "The Inhomogeneity of Magnetic Susceptibility in Vertebral Body Marrow", 8th Ann. Mtg. Society of Magn. Res. in Med., 217, (1989).
J. C. Ford, F. W. Wehrli, and D. A. Gusnard, "Quantification of the Intrinsic Magnetic Field Inhomogeneity of Trabecular Bone", Magn. Res. Imaging, 8, (Suppl. 1): 37, Feb. 1990.
J. C. Ford, F. W. Wehrli, and C. K. Watson, "In-Vivo Quantitative Characterization of Trabecular Bone by NMR Interferometry and Localized Proton Spectroscopy", 9th Ann. Mtg. of Society of Magn. Res. in Med. 1: 128, Nov. 1990.

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