Method and apparatus for determining base sequence of...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C536S023100, C536S024300

Reexamination Certificate

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11231998

ABSTRACT:
Disclosed herein is a method and apparatus for determining the base sequence of a nucleic acid molecule by cleaving a nucleic acid molecule of interest while controlling the cleavage site, measuring the change in mass which occurs in the nucleic acid molecule after the cleavage step, and acquiring the base information of the cleaved nucleic acid molecule from the data about the change in mass. The method and apparatus are based on the principle which is entirely different from that used for the conventional technique.

REFERENCES:
patent: 6074823 (2000-06-01), Koster
patent: 6245754 (1994-06-01), None
patent: 2004-16171 (2004-01-01), None
patent: 2004-125706 (2004-04-01), None
Saiki et al., Enzymatic Amplification of β-genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 230 : 1350-1354(1985).
Chehab et al. Detection of sickle cell anaemia and thalassemias. Nature 329 : 293-294 (1987).

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