Surgery: light – thermal – and electrical application – Light – thermal – and electrical application – Light application
Patent
1994-08-23
1996-06-04
Sykes, Angela D.
Surgery: light, thermal, and electrical application
Light, thermal, and electrical application
Light application
128633, A61B 500
Patent
active
055228682
ABSTRACT:
Levels of psoralen concentration in a biological detection target are determined so that an appropriate UVA light dose of PUVA therapy can be delivered to a biological treatment target. The appropriate therapy is determined by the product of the UVA light dose and psoralen concentration level. After determination of a baseline optical autofluoresence signal from the detection target, a first dosage of psoralen (preferably 8-methoxypsoralen [8-MOP]) is administered. Thereafter, the detection target is irradiated under the same conditions as the pre-psoralen irradiation. Then, the optical return from the psoralen-treated detection target is analyzed. A computer (86) compares the pre-psoralen optical return and psoralen-treated optical return to calculate a real time determination of the concentration level of psoralen in the treatment target. Then, then knowing the precise psoralen concentration level, a UV dosage level required to achieve the desired PUVA therapy can be precisely determined and applied to the treatment target. In some embodiments, the detection target is the treatment target and in vivo real time psoralen concentration is determined. Various forms of applicators (52, 452, 552, 652, 752) are provided for differing types of targets. Each applicator is mounted on an optical fiber bundle (54). In some embodiments, the same optical fiber bundle (54) is employed to transmit the irradiation and optical return signals in the psoralen concentration determination, as well as to transmit the UVA for the PUVA therapy.
REFERENCES:
patent: 4545987 (1985-10-01), Giles et al.
patent: 4558700 (1985-12-01), Mutzhas
patent: 5116864 (1992-05-01), March et al.
patent: 5344433 (1994-09-01), Talmore
Gasparro, F., et al., Journal Investigative Dermatology 90, 234-236 (1988).
Schomacker, Kevin T., et al., "Ultraviolet Laser-Induced Fluorescence of Colonic Tissue: Basic Biology and Diagnostic Potential", Lasers in Surgery and Medicine 12:63-78 (1992).
Buckley Lisa A.
Jacques Steven L.
Prahl Scott A.
Nasser Jr. Robert L.
Sisters of Providence in Oregon
Sykes Angela D.
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