Optics: measuring and testing – By dispersed light spectroscopy – With sample excitation
Patent
1997-03-25
2000-10-31
Evans, F. L.
Optics: measuring and testing
By dispersed light spectroscopy
With sample excitation
356417, 2504581, 2502013, G01N 2164
Patent
active
061410969
ABSTRACT:
Fluorescently marked targets bind to a substrate 230 synthesized with polymer sequences at known locations. The targets are detected by exposing selected regions of the substrate 230 to light from a light source 100 and detecting the photons from the light fluoresced therefrom, and repeating the steps of exposure and detection until the substrate 230 is completely examined. The resulting data can be used to determine binding affinity of the targets to specific polymer sequences.
REFERENCES:
patent: 3798449 (1974-03-01), Reinheimer et al.
patent: 4180739 (1979-12-01), Abu-Shumays
patent: 4342905 (1982-08-01), Fujii et al.
patent: 4708494 (1987-11-01), Kleinerman
patent: 4786170 (1988-11-01), Groebler
patent: 4810869 (1989-03-01), Yabe et al.
patent: 4844614 (1989-07-01), Kelderman et al.
patent: 5091652 (1992-02-01), Mathies et al.
patent: 5143854 (1992-09-01), Pirrung et al.
patent: 5192980 (1993-03-01), Dixon et al.
patent: 5631734 (1997-05-01), Stern et al.
patent: 5861242 (1999-01-01), Chee et al.
Benschop et al., "Confocal compact scanning optical microscope based on compact disk technology," Chem. Abs. 114(26) : 1179-184, abstract No. 256643p, Jul. 1, 1991.
Ekins et al., "Development of microspot multianalyte ratiometric immunoassay using dual fluorescent-labelled antibodies," Analytica Chimica ACTA 227:73-96, Dec. 1, 1989.
Ekins et al., "Multianalyte microspot immunoassay-microanalytical 'compact disk'of the future, " Clin Chem. 37(11) :1955-1967, Nov. 1991.
Quesada et al., "High-sensitivity DNA detection with a laser-excited confocal fluorescent gel scanner," Biotechniques 10:616-625, (1991).
van der Voort et al., "Design and use of a computer controlled confocal microscope for biological applications," Scanning 7:68-78, 1985.
White et al., "An evaluation of confocal versus conventional imaging of biological structures by fluorescent light microcopy," J. Cell Biol. 105:41-48, Jul. 1987.
Yamamoto et al., "Features and applications of the laser scanning microscope," J. Mod. Optics 37:1691-1701, 1990.
Fiekowsky Peter
Stern David
Affymetrix Inc.
Evans F. L.
LandOfFree
Method and apparatus for detection of fluorescently labeled mate does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for detection of fluorescently labeled mate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for detection of fluorescently labeled mate will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2059000