Method and apparatus for detecting the presence of cancerous and

Details Method and apparatus for detecting the presence of cancerous and Method and apparatus for detecting the presence of cancerous and

1997-12-02

2000-06-27

Snay, Jeffrey

Chemistry: analytical and immunological testing

Biological cellular material tested

436 64, 436172, 422 8208, G01N 2164

Patent

active

060805846

ABSTRACT:
A method and apparatus for examining a cell smear for the purpose of detecting the presence of cancerous and precancerous cells located therein. In a preferred embodiment, the method comprises illuminating at least a portion of the cell smear with light of a first wavelength, whereby native fluorescence is emitted therefrom. Next, the intensity of native fluorescence emitted from the illuminated area is measured at a second wavelength and at a third wavelength as a function of location within the illuminated area. The first, second and third wavelengths are chosen so that the ratio of fluorescence intensities at the second and third wavelengths is indicative of a carcinomatous condition. Next, the ratio of intensities measured at the second and third wavelengths is determined to obtain a value for each location within the illuminated area. Finally, a map is generated of all the cells present within the illuminated area using the calculated values. The map not only shows the spatial distribution of cells located within the area but also indicates by color coding or shading the carcinomatous condition of each cell therein.

REFERENCES:
patent: 4755684 (1988-07-01), Leiner et al.
patent: 4930516 (1990-06-01), Alfano et al.
patent: 5042494 (1991-08-01), Alfano
patent: 5061075 (1991-10-01), Alfano et al.
patent: 5131398 (1992-07-01), Alfano et al.
patent: 5348018 (1994-09-01), Alfano et al.
patent: 5413108 (1995-05-01), Alfano
patent: 5450857 (1995-09-01), Garfield et al.
patent: 5474910 (1995-12-01), Alfano
patent: 5612540 (1997-03-01), Richards-Kortum et al.
patent: 5635402 (1997-06-01), Alfano et al.
Lohmann, W. et al, "Autofluorescence of tissue surrounding malignant tumors" Proc. SPIE-Int. Soc. Opt. Eng. (1998) vol. 3251 (Coherence Domain Optical Methods in Biomedical Science and Clinical Applications II) pp. 165-171.

Affiliated with

Also associated with

Rating

Method and apparatus for detecting the presence of cancerous and does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method and apparatus for detecting the presence of cancerous and, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for detecting the presence of cancerous and will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1783468