Textiles: fiber preparation
Patent
1975-06-26
1976-08-17
Wolk, Morris O.
Textiles: fiber preparation
23230B, 23253R, 195127, 204195B, 204 1T, 424 12, G01N 2110, G01N 3316
Patent
active
039752380
ABSTRACT:
A method and apparatus for optically detecting complexing of molecules in solution with surface-bound enzymes comprises slowly varying, in periodic fashion, the surface electrical potential so as to vary correspondingly the pH of the solution at the enzymatic sites through a range in which the Michaelis constant exhibits a relatively large change with pH variation. The potential is also oscillated over a smaller voltage range at a higher frequency. Phase sensitive detection of the output signal of an ellipsometer directed onto the surface provides a signal proportional to the concentration of complexing molecules.
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Bean Charles P.
Giaever Ivar
Cohen Joseph T.
General Electric Company
Marantz Sidney
Snyder Marvin
Squillaro Jerome C.
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