Liquid purification or separation – With means to add treating material – Chromatography
Reexamination Certificate
2007-07-10
2007-07-10
Therkorn, Ernest G. (Department: 1723)
Liquid purification or separation
With means to add treating material
Chromatography
C210S656000, C378S047000, C422S082080, C435S007100, C436S056000, C436S058000
Reexamination Certificate
active
10986519
ABSTRACT:
The method for screening binding between a target binder and potential pharmaceutical chemicals involves sending a solution (preferably an aqueous solution) of the target binder through a conduit to a size exclusion filter, the target binder being too large to pass through the size exclusion filter, and then sending a solution of one or more potential pharmaceutical chemicals (preferably an aqueous solution) through the same conduit to the size exclusion filter after target binder has collected on the filter. The potential pharmaceutical chemicals are small enough to pass through the filter. Afterwards, x-rays are sent from an x-ray source to the size exclusion filter, and if the potential pharmaceutical chemicals form a complex with the target binder, the complex produces an x-ray fluorescence signal having an intensity that indicates that a complex has formed.
REFERENCES:
patent: 4745285 (1988-05-01), Recktenwald et al.
patent: 4832881 (1989-05-01), Arnold et al.
patent: 5482867 (1996-01-01), Barrett et al.
patent: 5506107 (1996-04-01), Cunningham et al.
patent: 5641640 (1997-06-01), Hanning
patent: 5965456 (1999-10-01), Malmqvist et al.
patent: 6147344 (2000-11-01), Annis et al.
patent: 6225132 (2001-05-01), Drukier et al.
patent: 6344334 (2002-02-01), Ellman et al.
patent: 6395169 (2002-05-01), Hindsgaul et al.
patent: 6496562 (2002-12-01), Henrich et al.
patent: 2003/0020254 (2003-01-01), Weaver
patent: 2003/0027129 (2003-02-01), Warner
George J. Havrilla et al., “Flow Method and Apparatus for Screening Chemicals Using Micro X-Ray Fluorescence,” U.S. Appl. No. 10/206,524, filed Jul. 25, 2002.
Bruce Alberts, Dennis Bray, Julian Lewis, Martin Raff, Keith Roberts, and James D. Watson, “Molecular Biology of the Cell,” Second Edition, pp. 159-160, 1989.
M. C. Ringo, M. S. Huhta, G. Shea-McCarthy, J. E. Penner-Hahn, and C. E. Evans, “On-Line X-ray Fluorescence Detection for Capillary Electrophoresis Separations,” Nuclear Instruments and Methods in Physics Research B, vol. 149, pp. 177-181, 1999.
Stephanie E. Mann, Moira C. Ringo, Grace Shea-McCarthy, James Penner-Hahn, and Christine E. Evans, “Element-Specific Detection in Capillary Electrophoresis Using X-ray Fluorescence Spectroscopy,” Anal. Chem, vol. 72, No. 8, pp. 1754-1758, 2000.
C. Vogt, J. Vogt and H. Wittrisch, “Element-Sensitive X-ray Detection for Capillary Electrophoresis,” Journal of Chromatography A, vol. 727, pp. 301-310, 1996.
Thomasin C. Miller, Martha R. Joseph, George J. Havrilla, Cris Lewis, and Vahid Majid, “Capillary Electrophoresis Micro X-ray Fluorescence: A Tool for Benchtop Elemental Analysis,” Analytical Chemistry, vol. 75, pp. 2048-2053, 2003.
Havrilla George J.
Miller Thomasin C.
Warner Benjamin P.
Wells Cyndi A.
Borkowsky Samuel L.
Los Alamos National Security LLC
Therkorn Ernest G.
LandOfFree
Method and apparatus for detecting chemical binding does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method and apparatus for detecting chemical binding, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method and apparatus for detecting chemical binding will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3756562