Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1999-02-08
1999-12-07
Stucker, Jeffrey
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435 71, 435 79, 435 792, 435 18, 435974, 435975, 436518, 436 64, 436815, 530350, 53038826, C12Q 170
Patent
active
059981326
ABSTRACT:
HIV- and influenza virus-infected cells secrete .alpha.-N-acetylgalactosaminidase into the blood stream. Secretion of .alpha.-N-acetylgalactosaminidase is also associated with cancer. Elevated levels of .alpha.-N-acetylgalactosaminidase in the blood stream result in the deglycosylation of the Gc protein. This inactivates the MAF precursor activity of the Gc protein, leading to immunosuppression. Thus, the .alpha.-N-acetylgalactosaminidase activity in a patient's bloodstream can serve as a diagnostic and prognostic index. Antibody-sandwich ELISA methods and kits for .alpha.-N-acetylgalactosaminidase as an antigen were developed to detect serum or plasma .alpha.-N-acetylgalactosaminidase activity in patients and are used as a diagnostic/prognostic index.
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