Method and apparatus for detecting cancer, influenza, or HIV bas

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

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435 71, 435 79, 435 792, 435 18, 435974, 435975, 436518, 436 64, 436815, 530350, 53038826, C12Q 170

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059981326

ABSTRACT:
HIV- and influenza virus-infected cells secrete .alpha.-N-acetylgalactosaminidase into the blood stream. Secretion of .alpha.-N-acetylgalactosaminidase is also associated with cancer. Elevated levels of .alpha.-N-acetylgalactosaminidase in the blood stream result in the deglycosylation of the Gc protein. This inactivates the MAF precursor activity of the Gc protein, leading to immunosuppression. Thus, the .alpha.-N-acetylgalactosaminidase activity in a patient's bloodstream can serve as a diagnostic and prognostic index. Antibody-sandwich ELISA methods and kits for .alpha.-N-acetylgalactosaminidase as an antigen were developed to detect serum or plasma .alpha.-N-acetylgalactosaminidase activity in patients and are used as a diagnostic/prognostic index.

REFERENCES:
patent: 5712104 (1998-01-01), Yamamoto
Yamamoto, N. and Homma, S., Vitamin D.sub.3 binding protein (group-specific component, Gc) is a precusrsor for the macrophage activating signal from lysophosphatidylcholine-treated lymphocytes. Proc. Natl. Acad. Sci. USA, 88:8539-8543 (1991).
Bradford, M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal, Biochem, 72:248-254 (1976).
Yamamoto N. Structural definition of a potent macrophage activating factor derived from vitamin D.sub.3 binding protein with adjuvant activity for antibody production Molecular Immunol. 33:1157-1164 (1996).
Genomics, vol. 16, issued 1993, Witke et al., "Complete Structure of the Human Gc Gene: Differences and Similarities Between Members of the Albumin Gene Family", pp. 751-754.
Biochimica et Biophysica Acta, vol. 1216, issued 1993, Braun et al., "Sequence and Organization of the Human Vitamin D Binding Protein Gene", pp. 385-394.
Proceedings of the National Academy of Science, U.S.A., vol. 82, issue Dec. 1985, Yang et al. "Human Group-Specific Component (Gc) is a Member of the Albumin Family", pp. 7994-7998.
Biochemica et Biophysica Acta, vol. 871, issued 1986 Schoentgen et al., "Complete Amino Acid Sequence of Human Vitamin D-Binding Protein (Group-Specific Component): Evidence of a Three-fold Internal Homology as a Serum Albumin an alpha-Fetoprotein", pp. 189-198.
Yamamoto et al. "Structural Modification of Serum Vitamin D.sub.3 -Binding Protein and immunosuppression in AIDS Patients", AIDS Research and Human Retroviruses, vol. 11, No. 11 (Nov. 1995), pp. 1373-1378. RC607.A26.A35.

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